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P2X and P2Y receptor signaling in red blood cells

Overview of attention for article published in Frontiers in Molecular Biosciences, October 2015
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Title
P2X and P2Y receptor signaling in red blood cells
Published in
Frontiers in Molecular Biosciences, October 2015
DOI 10.3389/fmolb.2015.00060
Pubmed ID
Authors

Ronald Sluyter

Abstract

Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively. P2 receptors comprise P2X and P2Y receptors, and have well-established roles in leukocyte and platelet biology. Emerging evidence indicates important roles for these receptors in red blood cells. P2 receptor activation stimulates a number of signaling pathways in progenitor red blood cells resulting in microparticle release, reactive oxygen species formation, and apoptosis. Likewise, activation of P2 receptors in mature red blood cells stimulates signaling pathways mediating volume regulation, eicosanoid release, phosphatidylserine exposure, hemolysis, impaired ATP release, and susceptibility or resistance to infection. This review summarizes the distribution of P2 receptors in red blood cells, and outlines the functions of P2 receptor signaling in these cells and its implications in red blood cell biology.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 45 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 27%
Student > Ph. D. Student 6 13%
Student > Bachelor 4 9%
Student > Master 4 9%
Other 3 7%
Other 6 13%
Unknown 10 22%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 11 24%
Agricultural and Biological Sciences 9 20%
Medicine and Dentistry 3 7%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Veterinary Science and Veterinary Medicine 2 4%
Other 6 13%
Unknown 12 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2015.
All research outputs
#18,429,829
of 22,831,537 outputs
Outputs from Frontiers in Molecular Biosciences
#1,951
of 3,780 outputs
Outputs of similar age
#204,920
of 284,642 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#7
of 15 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,780 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,642 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.