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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Characterization of the Olfactory Receptors Expressed in Human Spermatozoa
|
|---|---|
| Published in |
Frontiers in Molecular Biosciences, January 2016
|
| DOI | 10.3389/fmolb.2015.00073 |
| Pubmed ID | |
| Authors |
Caroline Flegel, Felix Vogel, Adrian Hofreuter, Benjamin S. P. Schreiner, Sandra Osthold, Sophie Veitinger, Christian Becker, Norbert H. Brockmeyer, Michael Muschol, Gunther Wennemuth, Janine Altmüller, Hanns Hatt, Günter Gisselmann |
| Abstract |
The detection of external cues is fundamental for human spermatozoa to locate the oocyte in the female reproductive tract. This task requires a specific chemoreceptor repertoire that is expressed on the surface of human spermatozoa, which is not fully identified to date. Olfactory receptors (ORs) are candidate molecules and have been attributed to be involved in sperm chemotaxis and chemokinesis, indicating an important role in mammalian spermatozoa. An increasing importance has been suggested for spermatozoal RNA, which led us to investigate the expression of all 387 OR genes. This study provides the first comprehensive analysis of OR transcripts in human spermatozoa of several individuals by RNA-Seq. We detected 91 different transcripts in the spermatozoa samples that could be aligned to annotated OR genes. Using stranded mRNA-Seq, we detected a class of these putative OR transcripts in an antisense orientation, indicating a different function, rather than coding for a functional OR protein. Nevertheless, we were able to detect OR proteins in various compartments of human spermatozoa, indicating distinct functions in human sperm. A panel of various OR ligands induced Ca(2+) signals in human spermatozoa, which could be inhibited by mibefradil. This study indicates that a variety of ORs are expressed at the mRNA and protein level in human spermatozoa. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| France | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 4 | 80% |
| Members of the public | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 100 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 19% |
| Student > Bachelor | 13 | 13% |
| Researcher | 13 | 13% |
| Student > Master | 12 | 12% |
| Student > Doctoral Student | 8 | 8% |
| Other | 16 | 16% |
| Unknown | 20 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 26% |
| Agricultural and Biological Sciences | 23 | 23% |
| Medicine and Dentistry | 11 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Veterinary Science and Veterinary Medicine | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 24 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2022.
All research outputs
#5,273,918
of 25,770,491 outputs
Outputs from Frontiers in Molecular Biosciences
#514
of 4,767 outputs
Outputs of similar age
#82,047
of 402,275 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#3
of 15 outputs
Altmetric has tracked 25,770,491 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,767 research outputs from this source. They receive a mean Attention Score of 3.6. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 402,275 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.