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A Comparative Study of the Effect of Leukoreduction and Pre-storage Leukodepletion on Red Blood Cells during Storage

Overview of attention for article published in Frontiers in Molecular Biosciences, April 2016
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Title
A Comparative Study of the Effect of Leukoreduction and Pre-storage Leukodepletion on Red Blood Cells during Storage
Published in
Frontiers in Molecular Biosciences, April 2016
DOI 10.3389/fmolb.2016.00013
Pubmed ID
Authors

Thelma A. Pertinhez, Emanuela Casali, Fabio Baroni, Pamela Berni, Roberto Baricchi, Alberto Spisni

Abstract

Blood transfusion is a fundamental therapy in numerous pathological conditions. Regrettably, many clinical reports describe adverse transfusion's drawbacks due to red blood cells alterations during storage. Thus, the possibility for a blood bank to ameliorate the quality of the erythrocyte concentrates units is crucial to improve clinical results and reduce transfusion adverse occurrences. Leukodepletion is a pre-storage treatment recognized to better preserve the quality of red blood cells with respect to leukoreduction. Aim of this work is to unravel the biochemical and biophysical basis that sustain the good clinical outcomes associated to the use of leukodepleted erythrocytes units. Erythrocytes concentrates were prepared as leukoreduced (n = 8) and pre-storage leukodepleted (n = 8) and then studied during 6 weeks in blood bank conditions. Overall, the data indicate that leukodepletion not only provide red blood cells with an appropriate amount of nutrients for a longer time but also selects red blood cells characterized by a more resilient plasma membrane fit to prolong their viability. We believe these results will stimulate new ideas to further optimize the current storage protocols.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Other 5 17%
Student > Bachelor 5 17%
Researcher 4 13%
Student > Master 3 10%
Student > Ph. D. Student 2 7%
Other 3 10%
Unknown 8 27%
Readers by discipline Count As %
Medicine and Dentistry 3 10%
Immunology and Microbiology 3 10%
Biochemistry, Genetics and Molecular Biology 3 10%
Chemical Engineering 2 7%
Nursing and Health Professions 2 7%
Other 8 27%
Unknown 9 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2016.
All research outputs
#18,453,763
of 22,865,319 outputs
Outputs from Frontiers in Molecular Biosciences
#1,959
of 3,800 outputs
Outputs of similar age
#219,232
of 299,499 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#11
of 16 outputs
Altmetric has tracked 22,865,319 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,800 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.