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Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance

Overview of attention for article published in Frontiers in Molecular Biosciences, January 2018
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Title
Insight into Two ABC Transporter Families Involved in Lantibiotic Resistance
Published in
Frontiers in Molecular Biosciences, January 2018
DOI 10.3389/fmolb.2017.00091
Pubmed ID
Authors

Rebecca Clemens, Julia Zaschke-Kriesche, Sakshi Khosa, Sander H. J. Smits

Abstract

Antimicrobial peptides, which contain (methyl)-lanthionine-rings are called lantibiotics. They are produced by several Gram-positive bacteria and are mainly active against these bacteria. Although these are highly potent antimicrobials, some human pathogenic bacteria express specific ABC transporters that confer resistance and counteract their antimicrobial activity. Two distinct ABC transporter families are known to be involved in this process. These are the Cpr- and Bce-type ABC transporter families, named after their involvement in cationic peptide resistance in Clostridium difficile, and bacitracin efflux in Bacillus subtilis, respectively. Both resistance systems differentiate to each other in terms of the proteins involved. Here, we summarize the current knowledge and describe the divergence as well as the common features present in both the systems to confer lantibiotic resistance.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 22%
Student > Bachelor 9 17%
Student > Master 6 11%
Student > Ph. D. Student 5 9%
Professor > Associate Professor 3 6%
Other 8 15%
Unknown 11 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 17 31%
Agricultural and Biological Sciences 10 19%
Chemistry 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Immunology and Microbiology 2 4%
Other 5 9%
Unknown 15 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2018.
All research outputs
#17,926,658
of 23,016,919 outputs
Outputs from Frontiers in Molecular Biosciences
#1,703
of 3,870 outputs
Outputs of similar age
#310,204
of 441,076 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#23
of 39 outputs
Altmetric has tracked 23,016,919 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,870 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 441,076 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.