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Importance of Functional Loss of FUS in FTLD/ALS

Overview of attention for article published in Frontiers in Molecular Biosciences, May 2018
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Title
Importance of Functional Loss of FUS in FTLD/ALS
Published in
Frontiers in Molecular Biosciences, May 2018
DOI 10.3389/fmolb.2018.00044
Pubmed ID
Authors

Shinsuke Ishigaki, Gen Sobue

Abstract

Fused in sarcoma (FUS) is an RNA binding protein that regulates RNA metabolism including alternative splicing, transcription, and RNA transportation. FUS is genetically and pathologically involved in frontotemporal lobar degeneration (FTLD)/amyotrophic lateral sclerosis (ALS). Multiple lines of evidence across diverse models suggest that functional loss of FUS can lead to neuronal dysfunction and/or neuronal cell death. Loss of FUS in the nucleus can impair alternative splicing and/or transcription, whereas dysfunction of FUS in the cytoplasm, especially in the dendritic spines of neurons, can cause mRNA destabilization. Alternative splicing of the MAPT gene at exon 10, which generates 4-repeat Tau (4R-Tau) and 3-repeat Tau (3R-Tau), is one of the most impactful targets regulated by FUS. Additionally, loss of FUS function can affect dendritic spine maturations by destabilizing mRNAs such as Glutamate receptor 1 (GluA1), a major AMPA receptor, and Synaptic Ras GTPase-activating protein 1 (SynGAP1). Moreover, FUS is involved in axonal transport and morphological maintenance of neurons. These findings indicate that a biological link between loss of FUS function, Tau isoform alteration, aberrant post-synaptic function, and phenotypic expression might lead to the sequential cascade culminating in FTLD. Thus, to facilitate development of early disease markers and/or therapeutic targets of FTLD/ALS it is critical that the functions of FUS and its downstream pathways are unraveled.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 146 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 146 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 27 18%
Student > Master 22 15%
Student > Bachelor 18 12%
Researcher 12 8%
Student > Doctoral Student 9 6%
Other 16 11%
Unknown 42 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 46 32%
Neuroscience 21 14%
Agricultural and Biological Sciences 13 9%
Medicine and Dentistry 11 8%
Engineering 3 2%
Other 8 5%
Unknown 44 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2018.
All research outputs
#17,948,821
of 23,047,237 outputs
Outputs from Frontiers in Molecular Biosciences
#1,711
of 3,883 outputs
Outputs of similar age
#236,863
of 326,458 outputs
Outputs of similar age from Frontiers in Molecular Biosciences
#24
of 33 outputs
Altmetric has tracked 23,047,237 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,883 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.