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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Amylin Receptor: A Common Pathophysiological Target in Alzheimer’s Disease and Diabetes Mellitus
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, January 2013
|
| DOI | 10.3389/fnagi.2013.00042 |
| Pubmed ID | |
| Authors |
Wen Fu, Aarti Patel, Jack H. Jhamandas |
| Abstract |
Amylin (islet amyloid polypeptide) and amyloid-beta (Aβ) protein, which are deposited within pancreatic islets of diabetics and brains of Alzheimer's patients respectively, share many biophysical and physiological properties. Emerging evidence indicates that the amylin receptor is a putative target receptor for the actions of human amylin and Aβ in the brain. The amylin receptor consists of the calcitonin receptor dimerized with a receptor activity-modifying protein and is widely distributed within central nervous system. Both amylin and Aβ directly activate this G protein-coupled receptor and trigger multiple common intracellular signal transduction pathways that can culminate in apoptotic cell death. Moreover, amylin receptor antagonists can block both the biological and neurotoxic effects of human amylin and Aβ. Amylin receptors thus appear to be involved in the pathophysiology of Alzheimer's disease and diabetes, and could serve as a molecular link between the two conditions that are associated epidemiologically. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 79 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 19% |
| Researcher | 15 | 19% |
| Student > Bachelor | 13 | 16% |
| Student > Master | 10 | 13% |
| Professor > Associate Professor | 5 | 6% |
| Other | 12 | 15% |
| Unknown | 10 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 20% |
| Agricultural and Biological Sciences | 15 | 19% |
| Medicine and Dentistry | 11 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
| Neuroscience | 7 | 9% |
| Other | 13 | 16% |
| Unknown | 11 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2013.
All research outputs
#20,198,525
of 22,716,996 outputs
Outputs from Frontiers in Aging Neuroscience
#4,258
of 4,734 outputs
Outputs of similar age
#248,774
of 280,757 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#72
of 77 outputs
Altmetric has tracked 22,716,996 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,734 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,757 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.