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The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults

Overview of attention for article published in Frontiers in Aging Neuroscience, January 2013
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Title
The Serum Concentration of the Calcium Binding Protein S100B is Positively Associated with Cognitive Performance in Older Adults
Published in
Frontiers in Aging Neuroscience, January 2013
DOI 10.3389/fnagi.2013.00061
Pubmed ID
Authors

Virginie Lam, Matthew A. Albrecht, Ryusuke Takechi, Corey Giles, Anthony P. James, Jonathan K. Foster, John C. L. Mamo

Abstract

S100B is a calcium binding peptide produced predominantly by astroglial cells in the central nervous system. S100B paradoxically has neurotrophic and apoptotic effects, dependent on extracellular concentration. This study investigated the relationship between serum S100B levels and neuropsychological performance across a range of cognitive domains in healthy older aged adults. A cohort of 219 participants between the ages of 43 and 84 years (141 female) were recruited. Subjects provided a fasting blood sample for S100B measurement (Mean = 0.24 ng/mL, SD = 0.14) and completed a battery of neuropsychological tests. S100B concentrations (both with and without the covariates of age and sex) were positively associated with the following measures of cognitive performance: digit-symbol coding, Stroop test, and measures of verbal ability. The results from this study show that serum S100B is positively associated with better cognitive performance in healthy older adults.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 17%
Student > Bachelor 5 11%
Student > Master 4 9%
Student > Ph. D. Student 4 9%
Other 3 7%
Other 6 13%
Unknown 16 35%
Readers by discipline Count As %
Psychology 6 13%
Neuroscience 6 13%
Medicine and Dentistry 4 9%
Agricultural and Biological Sciences 4 9%
Chemistry 2 4%
Other 7 15%
Unknown 17 37%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 January 2019.
All research outputs
#18,349,015
of 23,577,761 outputs
Outputs from Frontiers in Aging Neuroscience
#3,986
of 4,973 outputs
Outputs of similar age
#214,474
of 284,974 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#62
of 77 outputs
Altmetric has tracked 23,577,761 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,973 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.4. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,974 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.