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Attention Score in Context
| Title |
Age-dependent effect of Alzheimer’s risk variant of CLU on EEG alpha rhythm in non-demented adults
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, January 2013
|
| DOI | 10.3389/fnagi.2013.00086 |
| Pubmed ID | |
| Authors |
Natalya Ponomareva, Tatiana Andreeva, Maria Protasova, Lev Shagam, Daria Malina, Andrei Goltsov, Vitaly Fokin, Andrei Mitrofanov, Evgeny Rogaev |
| Abstract |
Polymorphism in the genomic region harboring the CLU gene (rs11136000) has been associated with the risk for Alzheimer's disease (AD). CLU C allele is assumed to confer risk for AD and the allele T may have a protective effect. We investigated the influence of the AD-associated CLU genotype on a common neurophysiological trait of brain activity (resting-state alpha-rhythm activity) in non-demented adults and elucidated whether this influence is modified over the course of aging. We examined quantitative electroencephalography (EEG) in a cohort of non-demented individuals (age range 20-80) divided into young (age range 20-50) and old (age range 51-80) cohorts and stratified by CLU polymorphism. To rule out the effect of the apolipoprotein E (ApoE) genotype on EEG characteristics, only subjects without the ApoE ε4 allele were included in the study. The homozygous presence of the AD risk variant CLU CC in non-demented subjects was associated with an increase of alpha3 absolute power. Moreover, the influence of CLU genotype on alpha3 was found to be higher in the subjects older than 50 years of age. The study also showed age-dependent alterations of alpha topographic distribution that occur independently of the CLU genotype. The increase of upper alpha power has been associated with hippocampal atrophy in patients with mild cognitive impairment (Moretti etal., 2012a). In our study, the CLU CC-dependent increase in upper alpha rhythm, particularly enhanced in elderly non-demented individuals, may imply that the genotype is related to preclinical dysregulation of hippocampal neurophysiology in aging and that this factor may contribute to the pathogenesis of AD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Netherlands | 1 | 1% |
| Unknown | 78 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 16% |
| Student > Master | 12 | 15% |
| Student > Ph. D. Student | 11 | 14% |
| Student > Bachelor | 7 | 9% |
| Student > Doctoral Student | 5 | 6% |
| Other | 12 | 15% |
| Unknown | 20 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 14 | 18% |
| Agricultural and Biological Sciences | 10 | 13% |
| Psychology | 10 | 13% |
| Engineering | 6 | 8% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Other | 13 | 16% |
| Unknown | 22 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2019.
All research outputs
#17,731,162
of 22,769,322 outputs
Outputs from Frontiers in Aging Neuroscience
#3,779
of 4,753 outputs
Outputs of similar age
#210,372
of 280,936 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#62
of 77 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,753 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,936 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.