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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, March 2014
|
| DOI | 10.3389/fnagi.2014.00051 |
| Pubmed ID | |
| Authors |
Marta Cosín-Tomás, María J. Alvarez-López, Sandra Sanchez-Roige, Jaume F. Lalanza, Sergi Bayod, Coral Sanfeliu, Merce Pallàs, Rosa M. Escorihuela, Perla Kaliman |
| Abstract |
The senescence-accelerated SAMP8 mouse model displays features of cognitive decline and Alzheimer's disease. With the purpose of identifying potential epigenetic markers involved in aging and neurodegeneration, here we analyzed the expression of 84 mature miRNAs, the expression of histone-acetylation regulatory genes and the global histone acetylation in the hippocampus of 8-month-old SAMP8 mice, using SAMR1 mice as control. We also examined the modulation of these parameters by 8 weeks of voluntary exercise. Twenty-one miRNAs were differentially expressed between sedentary SAMP8 and SAMR1 mice and seven miRNAs were responsive to exercise in both strains. SAMP8 mice showed alterations in genes involved in protein acetylation homeostasis such as Sirt1 and Hdac6 and modulation of Hdac3 and Hdac5 gene expression by exercise. Global histone H3 acetylation levels were reduced in SAMP8 compared with SAMR1 mice and reached control levels in response to exercise. In sum, data presented here provide new candidate epigenetic markers for aging and neurodegeneration and suggest that exercise training may prevent or delay some epigenetic alterations associated with accelerated aging. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| Argentina | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 122 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 2% |
| Chile | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 16% |
| Student > Master | 19 | 16% |
| Student > Bachelor | 15 | 12% |
| Researcher | 14 | 11% |
| Student > Doctoral Student | 9 | 7% |
| Other | 22 | 18% |
| Unknown | 24 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 25 | 20% |
| Agricultural and Biological Sciences | 23 | 19% |
| Medicine and Dentistry | 15 | 12% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Sports and Recreations | 5 | 4% |
| Other | 15 | 12% |
| Unknown | 30 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 May 2019.
All research outputs
#2,767,535
of 22,768,097 outputs
Outputs from Frontiers in Aging Neuroscience
#1,132
of 4,753 outputs
Outputs of similar age
#29,065
of 223,401 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#8
of 42 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,753 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 223,401 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.