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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Cortical Amyloid Beta in Cognitively Normal Elderly Adults is Associated with Decreased Network Efficiency within the Cerebro-Cerebellar System
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, March 2014
|
| DOI | 10.3389/fnagi.2014.00052 |
| Pubmed ID | |
| Authors |
Stefanie C. Steininger, Xinyang Liu, Anton Gietl, Michael Wyss, Simon Schreiner, Esmeralda Gruber, Valerie Treyer, Andrea Kälin, Sandra Leh, Alfred Buck, Roger M. Nitsch, Klaas P. Prüssmann, Christoph Hock, Paul G. Unschuld |
| Abstract |
Background: Deposition of cortical amyloid beta (Aβ) is a correlate of aging and a risk factor for Alzheimer disease (AD). While several higher order cognitive processes involve functional interactions between cortex and cerebellum, this study aims to investigate effects of cortical Aβ deposition on coupling within the cerebro-cerebellar system. Methods: We included 15 healthy elderly subjects with normal cognitive performance as assessed by neuropsychological testing. Cortical Aβ was quantified using (11)carbon-labeled Pittsburgh compound B positron-emission-tomography late frame signals. Volumes of brain structures were assessed by applying an automated parcelation algorithm to three dimensional magnetization-prepared rapid gradient-echo T1-weighted images. Basal functional network activity within the cerebro-cerebellar system was assessed using blood-oxygen-level dependent resting state functional magnetic resonance imaging at the high field strength of 7 T for measuring coupling between cerebellar seeds and cerebral gray matter. A bivariate regression approach was applied for identification of brain regions with significant effects of individual cortical Aβ load on coupling. Results: Consistent with earlier reports, a significant degree of positive and negative coupling could be observed between cerebellar seeds and cerebral voxels. Significant positive effects of cortical Aβ load on cerebro-cerebellar coupling resulted for cerebral brain regions located in inferior temporal lobe, prefrontal cortex, hippocampus, parahippocampal gyrus, and thalamus. Conclusion: Our findings indicate that brain amyloidosis in cognitively normal elderly subjects is associated with decreased network efficiency within the cerebro-cerebellar system. While the identified cerebral regions are consistent with established patterns of increased sensitivity for Aβ-associated neurodegeneration, additional studies are needed to elucidate the relationship between dysfunction of the cerebro-cerebellar system and risk for AD. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Switzerland | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 53 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 15% |
| Student > Bachelor | 7 | 13% |
| Student > Master | 7 | 13% |
| Researcher | 6 | 11% |
| Student > Doctoral Student | 3 | 5% |
| Other | 10 | 18% |
| Unknown | 14 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 12 | 22% |
| Neuroscience | 7 | 13% |
| Agricultural and Biological Sciences | 6 | 11% |
| Medicine and Dentistry | 6 | 11% |
| Unspecified | 3 | 5% |
| Other | 6 | 11% |
| Unknown | 15 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2020.
All research outputs
#14,781,203
of 22,756,196 outputs
Outputs from Frontiers in Aging Neuroscience
#3,335
of 4,747 outputs
Outputs of similar age
#137,903
of 242,918 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#30
of 42 outputs
Altmetric has tracked 22,756,196 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,747 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 242,918 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.