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Cardiorespiratory fitness mediates the effects of aging on cerebral blood flow

Overview of attention for article published in Frontiers in Aging Neuroscience, April 2014
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Title
Cardiorespiratory fitness mediates the effects of aging on cerebral blood flow
Published in
Frontiers in Aging Neuroscience, April 2014
DOI 10.3389/fnagi.2014.00059
Pubmed ID
Authors

Benjamin Zimmerman, Bradley P. Sutton, Kathy A. Low, Mark A. Fletcher, Chin Hong Tan, Nils Schneider-Garces, Yanfen Li, Cheng Ouyang, Edward L. Maclin, Gabriele Gratton, Monica Fabiani

Abstract

The brain's vasculature is likely to be subjected to the same age-related physiological and anatomical changes affecting the rest of the cardiovascular system. Since aerobic fitness is known to alleviate both cognitive and volumetric losses in the brain, it is important to investigate some of the possible mechanisms underlying these beneficial changes. Here we investigated the role that estimated cardiorespiratory fitness (eCRF) plays in determining the relationship between aging and cerebral blood flow (CBF) in a group of older adults (ages 55-85). Using arterial spin labeling to quantify CBF, we found that blood flow in the gray matter was positively correlated with eCRF and negatively correlated with age. Subsequent analyses revealed that eCRF fully mediated the effects of age on CBF in the gray matter, but not in the white matter. Additionally, regional measures of CBF were related to regional measures of brain volume. These findings provide evidence that age-related effects on cerebrovascular health and perfusion in older adults are largely influenced by their eCRF levels.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
Sweden 1 <1%
Colombia 1 <1%
Canada 1 <1%
United States 1 <1%
Unknown 115 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 17%
Researcher 21 17%
Student > Bachelor 17 14%
Student > Master 12 10%
Student > Doctoral Student 6 5%
Other 15 12%
Unknown 29 24%
Readers by discipline Count As %
Psychology 22 18%
Neuroscience 20 17%
Medicine and Dentistry 11 9%
Agricultural and Biological Sciences 10 8%
Sports and Recreations 6 5%
Other 18 15%
Unknown 34 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2014.
All research outputs
#15,299,919
of 22,754,104 outputs
Outputs from Frontiers in Aging Neuroscience
#3,577
of 4,747 outputs
Outputs of similar age
#134,571
of 227,779 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#41
of 56 outputs
Altmetric has tracked 22,754,104 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,747 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 227,779 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.