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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Differential effects of motor cortical excitability and plasticity in young and old individuals: a Transcranial Magnetic Stimulation (TMS) study
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, June 2014
|
| DOI | 10.3389/fnagi.2014.00111 |
| Pubmed ID | |
| Authors |
Shahid Bashir, Jennifer M. Perez, Jared C. Horvath, Cleofe Pena-Gomez, Marine Vernet, Anuhya Capia, Miguel Alonso-Alonso, Alvaro Pascual-Leone |
| Abstract |
Aging is associated with changes in the motor system that, over time, can lead to functional impairments and contribute negatively to the ability to recover after brain damage. Unfortunately, there are still many questions surrounding the physiological mechanisms underlying these impairments. We examined cortico-spinal excitability and plasticity in a young cohort (age range: 19-31) and an elderly cohort (age range: 47-73) of healthy right-handed individuals using navigated transcranial magnetic stimulation (nTMS). Subjects were evaluated with a combination of physiological [motor evoked potentials (MEPs), motor threshold (MT), intracortical inhibition (ICI), intracortical facilitation (ICF), and silent period (SP)] and behavioral [reaction time (RT), pinch force, 9 hole peg task (HPT)] measures at baseline and following one session of low-frequency (1 Hz) navigated repetitive TMS (rTMS) to the right (non-dominant) hemisphere. In the young cohort, the inhibitory effect of 1 Hz rTMS was significantly in the right hemisphere and a significant facilitatory effect was noted in the unstimulated hemisphere. Conversely, in the elderly cohort, we report only a trend toward a facilitatory effect in the unstimulated hemisphere, suggesting reduced cortical plasticity and interhemispheric communication. To this effect, we show that significant differences in hemispheric cortico-spinal excitability were present in the elderly cohort at baseline, with significantly reduced cortico-spinal excitability in the right hemisphere as compared to the left hemisphere. A correlation analysis revealed no significant relationship between cortical thickness of the selected region of interest (ROI) and MEPs in either young or old subjects prior to and following rTMS. When combined with our preliminary results, further research into this topic could lead to the development of neurophysiological markers pertinent to the diagnosis, prognosis, and treatment of neurological diseases characterized by monohemispheric damage and lateralized motor deficits. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 60% |
| United States | 1 | 20% |
| Unknown | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | <1% |
| Netherlands | 1 | <1% |
| Australia | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| New Zealand | 1 | <1% |
| Unknown | 136 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 21% |
| Student > Master | 22 | 15% |
| Student > Doctoral Student | 18 | 13% |
| Researcher | 16 | 11% |
| Student > Bachelor | 15 | 11% |
| Other | 26 | 18% |
| Unknown | 15 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 33 | 23% |
| Neuroscience | 27 | 19% |
| Psychology | 18 | 13% |
| Agricultural and Biological Sciences | 14 | 10% |
| Engineering | 5 | 4% |
| Other | 21 | 15% |
| Unknown | 24 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2014.
All research outputs
#7,349,573
of 23,344,526 outputs
Outputs from Frontiers in Aging Neuroscience
#2,665
of 4,928 outputs
Outputs of similar age
#70,742
of 230,591 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#27
of 60 outputs
Altmetric has tracked 23,344,526 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 4,928 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 230,591 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 60 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.