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Mendeley readers
Attention Score in Context
| Title |
DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests
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|---|---|
| Published in |
Frontiers in Aging Neuroscience, July 2014
|
| DOI | 10.3389/fnagi.2014.00167 |
| Pubmed ID | |
| Authors |
Xavier López-Gil, Iván Amat-Roldan, Raúl Tudela, Anna Castañé, Alberto Prats-Galino, Anna M. Planas, Tracy D. Farr, Guadalupe Soria |
| Abstract |
The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive function. We examined the feasibility of early diagnostic magnetic resonance imaging (MRI) to predict cognitive impairment before onset in an animal model of chronic hypertension: Spontaneously Hypertensive Rats. Cognitive performance was tested in an operant conditioning paradigm that evaluated learning, memory, and behavioral flexibility skills. Behavioral tests were coupled with longitudinal diffusion weighted imaging acquired with 126 diffusion gradient directions and 0.3 mm(3) isometric resolution at 10, 14, 18, 22, 26, and 40 weeks after birth. Diffusion weighted imaging was analyzed in two different ways, by regional characterization of diffusion tensor imaging (DTI) indices, and by assessing changes in structural brain network organization based on Q-Ball tractography. Already at the first evaluated times, DTI scalar maps revealed significant differences in many regions, suggesting loss of integrity in white and gray matter of spontaneously hypertensive rats when compared to normotensive control rats. In addition, graph theory analysis of the structural brain network demonstrated a significant decrease of hierarchical modularity, global and local efficacy, with predictive value as shown by regional three-fold cross validation study. Moreover, these decreases were significantly correlated with the behavioral performance deficits observed at subsequent time points, suggesting that the diffusion weighted imaging and connectivity studies can unravel neuroimaging alterations even overt signs of cognitive impairment become apparent. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 50% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 4% |
| Hong Kong | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 78 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 17 | 20% |
| Student > Ph. D. Student | 14 | 17% |
| Student > Bachelor | 9 | 11% |
| Professor | 6 | 7% |
| Student > Postgraduate | 5 | 6% |
| Other | 19 | 23% |
| Unknown | 13 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 18 | 22% |
| Agricultural and Biological Sciences | 15 | 18% |
| Medicine and Dentistry | 13 | 16% |
| Psychology | 8 | 10% |
| Computer Science | 3 | 4% |
| Other | 10 | 12% |
| Unknown | 16 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 April 2015.
All research outputs
#12,840,845
of 22,758,963 outputs
Outputs from Frontiers in Aging Neuroscience
#2,718
of 4,747 outputs
Outputs of similar age
#102,655
of 228,654 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#42
of 80 outputs
Altmetric has tracked 22,758,963 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,747 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,654 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.