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Mendeley readers
Attention Score in Context
| Title |
Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, August 2014
|
| DOI | 10.3389/fnagi.2014.00187 |
| Pubmed ID | |
| Authors |
Robert A. Marr, Daniel M. Hafez |
| Abstract |
Accumulation of the amyloid-beta (Aβ) peptide is a central factor in Alzheimer's disease (AD) pathogenesis as supported by continuing evidence. This review concisely summarizes this evidence supporting a critical role for Aβ in AD before discussing the clearance of this peptide. Mechanisms of clearance of Aβ are critical for preventing pathological elevations in Aβ concentration. Direct degradation of Aβ by endopeptidases has emerged as one important pathway for clearance. Of particular interest are endopeptidases that are sensitive to the neprilysin (NEP) inhibitors thiorphan and phosphoramidon (i.e., are "NEP-like") as these inhibitors induce a dramatic increase in Aβ levels in rodents. This review will focus on neprilysin-2 (NEP2), a NEP-like endopeptidase which cooperates with NEP to control Aβ levels in the brain. The evidence for the involvement of NEP2 in AD is discussed as well as the therapeutic relevance with regards to gene therapy and the development of molecular markers for the disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 142 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| South Africa | 1 | <1% |
| Portugal | 1 | <1% |
| Mexico | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 136 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 26 | 18% |
| Researcher | 21 | 15% |
| Student > Bachelor | 21 | 15% |
| Student > Ph. D. Student | 19 | 13% |
| Student > Doctoral Student | 11 | 8% |
| Other | 20 | 14% |
| Unknown | 24 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 18% |
| Biochemistry, Genetics and Molecular Biology | 20 | 14% |
| Medicine and Dentistry | 14 | 10% |
| Neuroscience | 13 | 9% |
| Chemistry | 12 | 8% |
| Other | 27 | 19% |
| Unknown | 30 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2014.
All research outputs
#5,665,864
of 22,763,032 outputs
Outputs from Frontiers in Aging Neuroscience
#2,284
of 4,752 outputs
Outputs of similar age
#53,442
of 231,144 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#27
of 84 outputs
Altmetric has tracked 22,763,032 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,752 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,144 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 76% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.