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X Demographics
Mendeley readers
Attention Score in Context
| Title |
n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, August 2014
|
| DOI | 10.3389/fnagi.2014.00220 |
| Pubmed ID | |
| Authors |
Debora Cutuli, Paola De Bartolo, Paola Caporali, Daniela Laricchiuta, Francesca Foti, Maurizio Ronci, Claudia Rossi, Cristina Neri, Gianfranco Spalletta, Carlo Caltagirone, Stefano Farioli-Vecchioli, Laura Petrosini |
| Abstract |
As major components of neuronal membranes, omega-3 polyunsaturated acids (n-3 PUFA) exhibit a wide range of regulatory functions, modulating from synaptic plasticity to neuroinflammation, from oxidative stress to neuroprotection. Recent human and animal studies indicated the n-3 PUFA neuroprotective properties in aging, with a clear negative correlation between n-3 PUFA levels and hippocampal deficits. The present multidimensional study was aimed at associating cognition, hippocampal neurogenesis, volume, neurodegeneration and metabolic correlates to verify n-3 PUFA neuroprotective effects in aging. To this aim 19 month-old mice were given n-3 PUFA mixture, or olive oil or no dietary supplement for 8 weeks during which hippocampal-dependent mnesic functions were tested. At the end of behavioral testing morphological and metabolic correlates were analyzed. n-3 PUFA supplemented aged mice exhibited better object recognition memory, spatial and localizatory memory, and aversive response retention, without modifications in anxiety levels in comparison to controls. These improved hippocampal cognitive functions occurred in the context of an enhanced cellular plasticity and a reduced neurodegeneration. In fact, n-3 PUFA supplementation increased hippocampal neurogenesis and dendritic arborization of newborn neurons, volume, neuronal density and microglial cell number, while it decreased apoptosis, astrocytosis and lipofuscin accumulation in the hippocampus. The increased levels of some metabolic correlates (blood Acetyl-L-Carnitine and brain n-3 PUFA concentrations) found in n-3 PUFA supplemented mice also pointed toward an effective neuroprotection. On the basis of the present results n-3 PUFA supplementation appears to be a useful tool in health promotion and cognitive decline prevention during aging. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Norway | 3 | 27% |
| United Kingdom | 1 | 9% |
| United States | 1 | 9% |
| Canada | 1 | 9% |
| Unknown | 5 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 82% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 112 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Unknown | 111 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 19% |
| Student > Master | 17 | 15% |
| Student > Bachelor | 16 | 14% |
| Student > Ph. D. Student | 12 | 11% |
| Student > Doctoral Student | 6 | 5% |
| Other | 15 | 13% |
| Unknown | 25 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 19% |
| Agricultural and Biological Sciences | 19 | 17% |
| Neuroscience | 18 | 16% |
| Biochemistry, Genetics and Molecular Biology | 11 | 10% |
| Psychology | 5 | 4% |
| Other | 10 | 9% |
| Unknown | 28 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2021.
All research outputs
#856,480
of 23,164,913 outputs
Outputs from Frontiers in Aging Neuroscience
#172
of 4,892 outputs
Outputs of similar age
#9,147
of 236,810 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#3
of 84 outputs
Altmetric has tracked 23,164,913 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,892 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 236,810 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.