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Mendeley readers
Attention Score in Context
| Title |
The effects of aging on the BTBR mouse model of autism spectrum disorder
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, September 2014
|
| DOI | 10.3389/fnagi.2014.00225 |
| Pubmed ID | |
| Authors |
Joan M. Jasien, Caitlin M. Daimon, Rui Wang, Bruce K. Shapiro, Bronwen Martin, Stuart Maudsley |
| Abstract |
Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by alterations in social functioning, communicative abilities, and engagement in repetitive or restrictive behaviors. The process of aging in individuals with autism and related neurodevelopmental disorders is not well understood, despite the fact that the number of individuals with ASD aged 65 and older is projected to increase by over half a million individuals in the next 20 years. To elucidate the effects of aging in the context of a modified central nervous system, we investigated the effects of age on the BTBR T + tf/j mouse, a well characterized and widely used mouse model that displays an ASD-like phenotype. We found that a reduction in social behavior persists into old age in male BTBR T + tf/j mice. We employed quantitative proteomics to discover potential alterations in signaling systems that could regulate aging in the BTBR mice. Unbiased proteomic analysis of hippocampal and cortical tissue of BTBR mice compared to age-matched wild-type controls revealed a significant decrease in brain derived neurotrophic factor and significant increases in multiple synaptic markers (spinophilin, Synapsin I, PSD 95, NeuN), as well as distinct changes in functional pathways related to these proteins, including "Neural synaptic plasticity regulation" and "Neurotransmitter secretion regulation." Taken together, these results contribute to our understanding of the effects of aging on an ASD-like mouse model in regards to both behavior and protein alterations, though additional studies are needed to fully understand the complex interplay underlying aging in mouse models displaying an ASD-like phenotype. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 25% |
| France | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 75% |
| Scientists | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 16% |
| Researcher | 8 | 13% |
| Student > Bachelor | 8 | 13% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Postgraduate | 4 | 6% |
| Other | 9 | 15% |
| Unknown | 17 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 16% |
| Medicine and Dentistry | 7 | 11% |
| Agricultural and Biological Sciences | 7 | 11% |
| Psychology | 6 | 10% |
| Biochemistry, Genetics and Molecular Biology | 5 | 8% |
| Other | 11 | 18% |
| Unknown | 16 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 June 2020.
All research outputs
#7,816,816
of 25,654,806 outputs
Outputs from Frontiers in Aging Neuroscience
#3,022
of 5,551 outputs
Outputs of similar age
#72,052
of 249,242 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#37
of 84 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 5,551 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,242 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 84 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 55% of its contemporaries.