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Mendeley readers
Attention Score in Context
| Title |
Decreased Default Mode Network connectivity correlates with age-associated structural and cognitive changes
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, September 2014
|
| DOI | 10.3389/fnagi.2014.00256 |
| Pubmed ID | |
| Authors |
Didac Vidal-Piñeiro, Cinta Valls-Pedret, Sara Fernández-Cabello, Eider M. Arenaza-Urquijo, Roser Sala-Llonch, Elisabeth Solana, Núria Bargalló, Carme Junqué, Emilio Ros, David Bartrés-Faz |
| Abstract |
Ageing entails cognitive and motor decline as well as brain changes such as loss of gray (GM) and white matter (WM) integrity, neurovascular and functional connectivity alterations. Regarding connectivity, reduced resting-state fMRI connectivity between anterior and posterior nodes of the Default Mode Network (DMN) relates to cognitive function and has been postulated to be a hallmark of ageing. However, the relationship between age-related connectivity changes and other neuroimaging-based measures in ageing is fragmentarily investigated. In a sample of 116 healthy elders we aimed to study the relationship between antero-posterior DMN connectivity and measures of WM integrity, GM integrity and cerebral blood flow (CBF), assessed with an arterial spin labeling sequence. First, we replicated previous findings demonstrating DMN connectivity decreases in ageing and an association between antero-posterior DMN connectivity and memory scores. The results showed that the functional connectivity between posterior midline structures and the medial prefrontal cortex was related to measures of WM and GM integrity but not to CBF. Gray and WM correlates of anterio-posterior DMN connectivity included, but were not limited to, DMN areas and cingulum bundle. These results resembled patterns of age-related vulnerability which was studied by comparing the correlates of antero-posterior DMN with age-effect maps. These age-effect maps were obtained after performing an independent analysis with a second sample including both young and old subjects. We argue that antero-posterior connectivity might be a sensitive measure of brain ageing over the brain. By using a comprehensive approach, the results provide valuable knowledge that may shed further light on DMN connectivity dysfunctions in ageing. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 201 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 3 | 1% |
| Germany | 2 | <1% |
| United States | 2 | <1% |
| Sweden | 1 | <1% |
| Canada | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 191 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 60 | 30% |
| Researcher | 25 | 12% |
| Student > Master | 21 | 10% |
| Student > Bachelor | 17 | 8% |
| Student > Doctoral Student | 12 | 6% |
| Other | 31 | 15% |
| Unknown | 35 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 52 | 26% |
| Psychology | 41 | 20% |
| Agricultural and Biological Sciences | 17 | 8% |
| Medicine and Dentistry | 16 | 8% |
| Engineering | 6 | 3% |
| Other | 23 | 11% |
| Unknown | 46 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2014.
All research outputs
#18,382,900
of 22,769,322 outputs
Outputs from Frontiers in Aging Neuroscience
#4,021
of 4,753 outputs
Outputs of similar age
#179,831
of 252,136 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#59
of 82 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,753 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 252,136 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 82 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.