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Mendeley readers
Attention Score in Context
| Title |
Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, October 2014
|
| DOI | 10.3389/fnagi.2014.00292 |
| Pubmed ID | |
| Authors |
Priscila Britto Campos, Bruna S. Paulsen, Stevens K. Rehen |
| Abstract |
In this review, we discuss insights gained through the use of stem cell preparations regarding the modeling of neurological diseases, the need for aging neurons derived from pluripotent stem cells to further advance the study of late-onset adult neurological diseases, and the extent to which mechanisms linked to the mismanagement of reactive oxygen species (ROS). The context of these issues can be revealed using the three disease states of Parkinson's (PD), Alzheimer's (AD), and schizophrenia, as considerable insights have been gained into these conditions through the use of stem cells in terms of disease etiologies and the role of oxidative stress. The latter subject is a primary area of interest of our group. After discussing the molecular models of accelerated aging, we highlight the role of ROS for the three diseases explored here. Importantly, we do not seek to provide an extensive account of all genetic mutations for each of the three disorders discussed in this review, but we aim instead to provide a conceptual framework that could maximize the gains from merging the approaches of stem cell microsystems and the study of oxidative stress in disease in order to optimize therapeutics and determine new molecular targets against oxidative stress that spare stem cell proliferation and development. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Canada | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 119 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 26% |
| Researcher | 24 | 20% |
| Student > Master | 18 | 15% |
| Student > Bachelor | 10 | 8% |
| Student > Doctoral Student | 8 | 7% |
| Other | 17 | 14% |
| Unknown | 13 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 30 | 25% |
| Biochemistry, Genetics and Molecular Biology | 22 | 18% |
| Agricultural and Biological Sciences | 20 | 17% |
| Medicine and Dentistry | 11 | 9% |
| Engineering | 5 | 4% |
| Other | 9 | 7% |
| Unknown | 24 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2014.
All research outputs
#15,310,081
of 22,770,070 outputs
Outputs from Frontiers in Aging Neuroscience
#3,579
of 4,754 outputs
Outputs of similar age
#151,491
of 260,281 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#44
of 73 outputs
Altmetric has tracked 22,770,070 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,754 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,281 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.