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Attention Score in Context
| Title |
Exceptional longevity and muscle and fitness related genotypes: a functional in vitro analysis and case-control association replication study with SNPs THRH rs7832552, IL6 rs1800795, and ACSL1 rs6552828
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|---|---|
| Published in |
Frontiers in Aging Neuroscience, May 2015
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| DOI | 10.3389/fnagi.2015.00059 |
| Pubmed ID | |
| Authors |
Noriyuki Fuku, Zi-hong He, Fabian Sanchis-Gomar, Helios Pareja-Galeano, Ye Tian, Yasumichi Arai, Yukiko Abe, Haruka Murakami, Motohiko Miyachi, Hirofumi Zempo, Hisashi Naito, Thomas Yvert, Zoraida Verde, Letizia Venturini, Carmen Fiuza-Luces, Alejandro Santos-Lozano, Gabriel Rodriguez-Romo, Giovanni Ricevuti, Nobuyoshi Hirose, Enzo Emanuele, Nuria Garatachea, Alejandro Lucia |
| Abstract |
There are several gene variants that are candidates to influence functional capacity in long-lived individuals. As such, their potential association with exceptional longevity (EL, i.e., reaching 100+ years) deserves analysis. Among them are rs7832552 in the thyrotropin-releasing hormone receptor (TRHR) gene, rs1800795 in the interleukin-6 (IL6) gene and rs6552828 in the coenzyme A synthetase long-chain 1 (ACSL1) gene. To gain insight into their functionality (which is yet unknown), here we determined for the first time luciferase gene reporter activity at the muscle tissue level in rs7832552 and rs6552828. We then compared allele/genotype frequencies of the 3 abovementioned variants among centenarians [n = 138, age range 100-111 years (114 women)] and healthy controls [n = 334, 20-50 years (141 women)] of the same ethnic and geographic origin (Spain). We also studied healthy centenarians [n = 79, 100-104 years (40 women)] and controls [n = 316, 27-81 years (156 women)] from Italy, and centenarians [n = 742, 100-116 years (623 women)] and healthy controls [n = 499, 23-59 years (356 women)] from Japan. The THRH rs7832552 T-allele and ACSL1 rs6552828 A-allele up-regulated luciferase activity compared to the C and G-allele, respectively (P = 0.001). Yet we found no significant association of EL with rs7832552, rs1800795 or rs6552828 in any of the 3 cohorts. Further research is needed with larger cohorts of centenarians of different origin as well as with younger old people. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 64 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 19% |
| Student > Master | 11 | 17% |
| Researcher | 9 | 14% |
| Professor | 5 | 8% |
| Student > Doctoral Student | 4 | 6% |
| Other | 13 | 20% |
| Unknown | 10 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 19% |
| Medicine and Dentistry | 8 | 13% |
| Agricultural and Biological Sciences | 7 | 11% |
| Sports and Recreations | 5 | 8% |
| Neuroscience | 3 | 5% |
| Other | 12 | 19% |
| Unknown | 17 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2015.
All research outputs
#20,273,512
of 22,805,349 outputs
Outputs from Frontiers in Aging Neuroscience
#4,285
of 4,768 outputs
Outputs of similar age
#222,674
of 264,547 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#59
of 63 outputs
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