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Biomarkers of postoperative delirium and cognitive dysfunction

Overview of attention for article published in Frontiers in Aging Neuroscience, June 2015
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Title
Biomarkers of postoperative delirium and cognitive dysfunction
Published in
Frontiers in Aging Neuroscience, June 2015
DOI 10.3389/fnagi.2015.00112
Pubmed ID
Authors

Ganna Androsova, Roland Krause, Georg Winterer, Reinhard Schneider

Abstract

Elderly surgical patients frequently experience postoperative delirium (POD) and the subsequent development of postoperative cognitive dysfunction (POCD). Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 264 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 <1%
Luxembourg 2 <1%
Italy 1 <1%
United States 1 <1%
Korea, Republic of 1 <1%
Unknown 257 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 40 15%
Student > Postgraduate 25 9%
Researcher 23 9%
Student > Bachelor 21 8%
Student > Doctoral Student 20 8%
Other 75 28%
Unknown 60 23%
Readers by discipline Count As %
Medicine and Dentistry 106 40%
Nursing and Health Professions 16 6%
Neuroscience 16 6%
Psychology 13 5%
Agricultural and Biological Sciences 13 5%
Other 36 14%
Unknown 64 24%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 June 2015.
All research outputs
#14,163,842
of 22,807,037 outputs
Outputs from Frontiers in Aging Neuroscience
#3,177
of 4,770 outputs
Outputs of similar age
#137,058
of 266,441 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#50
of 66 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,770 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,441 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 66 others from the same source and published within six weeks on either side of this one. This one is in the 24th percentile – i.e., 24% of its contemporaries scored the same or lower than it.