Title |
Menopause, obesity and inflammation: interactive risk factors for Alzheimer’s disease
|
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Published in |
Frontiers in Aging Neuroscience, July 2015
|
DOI | 10.3389/fnagi.2015.00130 |
Pubmed ID | |
Authors |
Amy Christensen, Christian J. Pike |
Abstract |
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, the development of which is regulated by several environmental and genetic risk factors. Two factors theorized to contribute to the initiation and/or progression of AD pathogenesis are age-related increases in inflammation and obesity. These factors may be particularly problematic in women. The onset of menopause in mid-life elevates the vulnerability of women to AD, an increased risk that is likely associated with the depletion of estrogens. Menopause is also linked with an abundance of additional changes, including increased central adiposity and inflammation. Here, we review the current literature to explore the interactions between obesity, inflammation, menopause and AD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | <1% |
Chile | 1 | <1% |
United States | 1 | <1% |
Germany | 1 | <1% |
Unknown | 197 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 30 | 15% |
Student > Bachelor | 29 | 14% |
Researcher | 27 | 13% |
Student > Ph. D. Student | 24 | 12% |
Student > Doctoral Student | 12 | 6% |
Other | 23 | 11% |
Unknown | 56 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 28 | 14% |
Neuroscience | 18 | 9% |
Agricultural and Biological Sciences | 17 | 8% |
Biochemistry, Genetics and Molecular Biology | 15 | 7% |
Nursing and Health Professions | 14 | 7% |
Other | 43 | 21% |
Unknown | 66 | 33% |