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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, October 2015
|
| DOI | 10.3389/fnagi.2015.00199 |
| Pubmed ID | |
| Authors |
Naoyuki Sato, Ryuichi Morishita |
| Abstract |
Diabetes is a risk factor for Alzheimer disease (AD). Apolipoprotein E (ApoE) and several genes related to AD have recently been identified by genome-wide association studies (GWAS) as being closely linked to lipid metabolism. Lipid metabolism and glucose-energy metabolism are closely related. Here, we review the emerging evidence regarding the roles of lipid and glucose metabolism in the modulation of β-amyloid, tau, and neurodegeneration during the pathogenesis of AD. Disruption of homeostasis of lipid and glucose metabolism affects production and clearance of β-amyloid and tau phosphorylation, and induces neurodegeneration. A more integrated understanding of the interactions among lipid, glucose, and protein metabolism is required to elucidate the pathogenesis of AD and to develop next-generation therapeutic options. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 17% |
| United States | 1 | 17% |
| United Kingdom | 1 | 17% |
| Canada | 1 | 17% |
| Switzerland | 1 | 17% |
| Unknown | 1 | 17% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | <1% |
| Unknown | 202 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 48 | 24% |
| Researcher | 28 | 14% |
| Student > Bachelor | 21 | 10% |
| Student > Master | 20 | 10% |
| Other | 11 | 5% |
| Other | 31 | 15% |
| Unknown | 44 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 47 | 23% |
| Biochemistry, Genetics and Molecular Biology | 31 | 15% |
| Agricultural and Biological Sciences | 21 | 10% |
| Medicine and Dentistry | 16 | 8% |
| Psychology | 7 | 3% |
| Other | 26 | 13% |
| Unknown | 55 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2018.
All research outputs
#2,341,410
of 22,830,751 outputs
Outputs from Frontiers in Aging Neuroscience
#748
of 4,780 outputs
Outputs of similar age
#35,535
of 283,600 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#7
of 49 outputs
Altmetric has tracked 22,830,751 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,780 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 283,600 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.