Title |
Astrocytes As the Main Players in Primary Degenerative Disorders of the Human Central Nervous System
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Published in |
Frontiers in Aging Neuroscience, March 2016
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DOI | 10.3389/fnagi.2016.00045 |
Pubmed ID | |
Authors |
Francisco Capani, Cecilia Quarracino, Roberto Caccuri, Roberto E. P. Sica |
Abstract |
Along the last years it has been demonstrated that non-neural cells play a major role in the pathogenesis of the primary degenerative disorders (PDDs) of the human central nervous system. Among them, astrocytes coordinate and participate in many different and complex metabolic processes, in close interaction with neurons. Moreover, increasing experimental evidence hints an early astrocytic dysfunction in these diseases. In this mini review we summarize the astrocytic behavior in PDDs, with special consideration to the experimental observations where astrocytic pathology precedes the development of neuronal dysfunction. We also suggest a different approach that could be consider in human investigations in Alzheimer's and Parkinson's disease. We believe that the study of PDDs with human brain samples may hold the key of a paradigmatic physiopathological process in which astrocytes might be the main players. |
X Demographics
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United Kingdom | 1 | 25% |
United States | 1 | 25% |
Switzerland | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 2 | 3% |
Switzerland | 1 | 1% |
Unknown | 70 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 16 | 22% |
Student > Master | 11 | 15% |
Student > Bachelor | 11 | 15% |
Researcher | 10 | 14% |
Professor | 5 | 7% |
Other | 12 | 16% |
Unknown | 8 | 11% |
Readers by discipline | Count | As % |
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Neuroscience | 19 | 26% |
Agricultural and Biological Sciences | 17 | 23% |
Medicine and Dentistry | 9 | 12% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Psychology | 2 | 3% |
Other | 7 | 10% |
Unknown | 12 | 16% |