Title |
Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons
|
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Published in |
Frontiers in Aging Neuroscience, June 2016
|
DOI | 10.3389/fnagi.2016.00116 |
Pubmed ID | |
Authors |
Tamara Logica, Stephanie Riviere, Mariana I. Holubiec, Rocío Castilla, George E. Barreto, Francisco Capani |
Abstract |
Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness. The interaction between neurons, astrocytes and endothelial cells plays a central role coupling energy supply with changes in neuronal activity. Traditionally, experimental research focused on neurons, whereas astrocytes have been more related to the damage mechanisms of PA. Astrocytes carry out a number of functions that are critical to normal nervous system function, including uptake of neurotransmitters, regulation of pH and ion concentrations, and metabolic support for neurons. In this work, we aim to review metabolic neuron-astrocyte interactions with the purpose of encourage further research in this area in the context of PA, which is highly complex and its mechanisms and pathways have not been fully elucidated to this day. |
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Geographical breakdown
Country | Count | As % |
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Argentina | 1 | 25% |
United States | 1 | 25% |
Spain | 1 | 25% |
Switzerland | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 55 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 20% |
Student > Master | 9 | 16% |
Student > Bachelor | 9 | 16% |
Researcher | 5 | 9% |
Other | 5 | 9% |
Other | 10 | 18% |
Unknown | 6 | 11% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 14 | 25% |
Neuroscience | 9 | 16% |
Biochemistry, Genetics and Molecular Biology | 5 | 9% |
Agricultural and Biological Sciences | 5 | 9% |
Business, Management and Accounting | 2 | 4% |
Other | 7 | 13% |
Unknown | 13 | 24% |