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Association between hs-CRP Levels and the Outcomes of Patients with Small-Artery Occlusion

Overview of attention for article published in Frontiers in Aging Neuroscience, August 2016
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Title
Association between hs-CRP Levels and the Outcomes of Patients with Small-Artery Occlusion
Published in
Frontiers in Aging Neuroscience, August 2016
DOI 10.3389/fnagi.2016.00191
Pubmed ID
Authors

Ruiying Qiu, Yuan Gao, Dongzhe Hou, Yajing Wang, Changshen Yu, Wanjun Wang, Shoufeng Liu, Chunlin Gao, Xiaoguang Tong, Jialing Wu

Abstract

High-sensitivity C-reactive protein (hs-CRP) is not only a marker of inflammation but also a prognostic factor for ischemic stroke. The objective of our study was to investigative the association between hs-CRP levels and outcomes of patients with small-artery occlusion (SAO). We selected 718 participants diagnosed with SAO (according to Trial of Org 10172 in Acute Stroke Treatment classification) using the stroke registry of the Department of Neurorehabilitation of Tianjin HuanHu Hospital. Hs-CRP values at admission were classified into 3 categories: <0.91 mg/L, 0.91 to <2.77 mg/L, and ≥2.77 mg/L. Patients were divided into two subgroups based on age: the younger subgroup (<75years) and the elder subgroup (≥75 years). Clinical outcomes were evaluated with the modified Rankin scale (mRS) 3 months after the onset of stroke. We examined the relationship between hs-CRP levels at the time of admission and mRS scores using multivariate logistic regression analysis. We also assessed the association between hs-CRP levels and patient outcomes according to age. Among 718 patients with SAO (mean age, 61.7 ± 11.3 years), median hs-CRP was 1.54 mg/L. Although 628 patients had a favorable outcome, and 90 patients had a poor outcome at 3 months after SAO. Compared with the lowest levels of hs-CRP, those highest levels of hs-CRP (hs-CRP > 2.77 mg/L) were at increased risk of poor outcome (adjusted odds ratio, 1.917; 95% CI, 1.050-3.500; P = 0.034), and more than twice the risk of poor outcome among patients in the younger subgroup (adjusted odds ratio, 2.092; 95% CI, 1.079-4.058; P = 0.029). These associations persisted after adjustment for confounding risk factors. However, hs-CRP levels were not significantly associated with outcome among patients in the elder subgroup. Elevated hs-CRP in patients with SAO is an independent predictor of poor prognosis; however, this association is only present in younger patients (<75 years).

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The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 20%
Student > Master 3 20%
Student > Ph. D. Student 3 20%
Student > Postgraduate 3 20%
Researcher 1 7%
Other 1 7%
Unknown 1 7%
Readers by discipline Count As %
Medicine and Dentistry 10 67%
Mathematics 1 7%
Biochemistry, Genetics and Molecular Biology 1 7%
Sports and Recreations 1 7%
Psychology 1 7%
Other 0 0%
Unknown 1 7%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 August 2016.
All research outputs
#20,337,210
of 22,882,389 outputs
Outputs from Frontiers in Aging Neuroscience
#4,315
of 4,817 outputs
Outputs of similar age
#317,036
of 361,775 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#59
of 72 outputs
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