You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Disrupted Nodal and Hub Organization Account for Brain Network Abnormalities in Parkinson’s Disease
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, November 2016
|
| DOI | 10.3389/fnagi.2016.00259 |
| Pubmed ID | |
| Authors |
Yuko Koshimori, Sang-Soo Cho, Marion Criaud, Leigh Christopher, Mark Jacobs, Christine Ghadery, Sarah Coakeley, Madeleine Harris, Romina Mizrahi, Clement Hamani, Anthony E. Lang, Sylvain Houle, Antonio P. Strafella |
| Abstract |
The recent application of graph theory to brain networks promises to shed light on complex diseases such as Parkinson's disease (PD). This study aimed to investigate functional changes in sensorimotor and cognitive networks in Parkinsonian patients, with a focus on inter- and intra-connectivity organization in the disease-associated nodal and hub regions using the graph theoretical analyses. Resting-state functional MRI data of a total of 65 participants, including 23 healthy controls (HCs) and 42 patients, were investigated in 120 nodes for local efficiency, betweenness centrality, and degree. Hub regions were identified in the HC and patient groups. We found nodal and hub changes in patients compared with HCs, including the right pre-supplementary motor area (SMA), left anterior insula, bilateral mid-insula, bilateral dorsolateral prefrontal cortex (DLPFC), and right caudate nucleus. In general, nodal regions within the sensorimotor network (i.e., right pre-SMA and right mid-insula) displayed weakened connectivity, with the former node associated with more severe bradykinesia, and impaired integration with default mode network regions. The left mid-insula also lost its hub properties in patients. Within the executive networks, the left anterior insular cortex lost its hub properties in patients, while a new hub region was identified in the right caudate nucleus, paralleled by an increased level of inter- and intra-connectivity in the bilateral DLPFC possibly representing compensatory mechanisms. These findings highlight the diffuse changes in nodal organization and regional hub disruption accounting for the distributed abnormalities across brain networks and the clinical manifestations of PD. |
X Demographics
The data shown below were collected from the profiles of 11 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 2 | 18% |
| United States | 2 | 18% |
| Canada | 2 | 18% |
| Switzerland | 1 | 9% |
| Italy | 1 | 9% |
| Unknown | 3 | 27% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 55% |
| Scientists | 3 | 27% |
| Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 23% |
| Researcher | 12 | 15% |
| Student > Bachelor | 7 | 9% |
| Other | 7 | 9% |
| Student > Doctoral Student | 6 | 8% |
| Other | 14 | 18% |
| Unknown | 15 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 29% |
| Medicine and Dentistry | 10 | 13% |
| Engineering | 6 | 8% |
| Psychology | 5 | 6% |
| Nursing and Health Professions | 4 | 5% |
| Other | 8 | 10% |
| Unknown | 23 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 November 2016.
All research outputs
#4,855,646
of 23,798,792 outputs
Outputs from Frontiers in Aging Neuroscience
#2,393
of 5,021 outputs
Outputs of similar age
#78,557
of 315,103 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#44
of 87 outputs
Altmetric has tracked 23,798,792 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,021 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.6. This one has gotten more attention than average, scoring higher than 52% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 315,103 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 87 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.