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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, April 2017
|
| DOI | 10.3389/fnagi.2017.00083 |
| Pubmed ID | |
| Authors |
Scott S. Shafiei, Marcos J. Guerrero-Muñoz, Diana L. Castillo-Carranza |
| Abstract |
Aging has long been considered as the main risk factor for several neurodegenerative disorders including a large group of diseases known as tauopathies. Even though neurofibrillary tangles (NFTs) have been examined as the main histopathological hallmark, they do not seem to play a role as the toxic entities leading to disease. Recent studies suggest that an intermediate form of tau, prior to NFT formation, the tau oligomer, is the true toxic species. However, the mechanisms by which tau oligomers trigger neurodegeneration remain unknown. This review summarizes recent findings regarding the role of tau oligomers in disease, including release from cells, propagation from affected to unaffected brain regions, uptake into cells, and toxicity via mitochondrial dysfunction. A greater understanding of tauopathies may lead to future advancements in regards to prevention and treatment. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 297 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Unknown | 296 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 62 | 21% |
| Researcher | 40 | 13% |
| Student > Master | 36 | 12% |
| Student > Bachelor | 32 | 11% |
| Student > Doctoral Student | 14 | 5% |
| Other | 28 | 9% |
| Unknown | 85 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 66 | 22% |
| Biochemistry, Genetics and Molecular Biology | 50 | 17% |
| Agricultural and Biological Sciences | 35 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 15 | 5% |
| Medicine and Dentistry | 14 | 5% |
| Other | 24 | 8% |
| Unknown | 93 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2017.
All research outputs
#1,951,778
of 22,963,381 outputs
Outputs from Frontiers in Aging Neuroscience
#548
of 4,832 outputs
Outputs of similar age
#39,805
of 308,980 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#25
of 116 outputs
Altmetric has tracked 22,963,381 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,832 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 308,980 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 116 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.