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Attention Score in Context
| Title |
Plasma Levels of Aβ42 and Tau Identified Probable Alzheimer’s Dementia: Findings in Two Cohorts
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, July 2017
|
| DOI | 10.3389/fnagi.2017.00226 |
| Pubmed ID | |
| Authors |
Lih-Fen Lue, Marwan N. Sabbagh, Ming-Jang Chiu, Naomi Jing, Noelle L. Snyder, Christopher Schmitz, Andre Guerra, Christine M. Belden, Ta-Fu Chen, Che-Chuan Yang, Shieh-Yueh Yang, Douglas G. Walker, Kewei Chen, Eric M. Reiman |
| Abstract |
The utility of plasma amyloid beta (Aβ) and tau levels for the clinical diagnosis of Alzheimer's disease (AD) dementia has been controversial. The main objective of this study was to compare Aβ42 and tau levels measured by the ultra-sensitive immunomagnetic reduction (IMR) assays in plasma samples collected at the Banner Sun Health Institute (BSHRI) (United States) with those from the National Taiwan University Hospital (NTUH) (Taiwan). Significant increase in tau levels were detected in AD subjects from both cohorts, while Aβ42 levels were increased only in the NTUH cohort. A regression model incorporating age showed that tau levels identified probable ADs with 81 and 96% accuracy in the BSHRI and NTUH cohorts, respectively, while computed products of Aβ42 and tau increased the accuracy to 84% in the BSHRI cohorts. Using 382.68 (pg/ml)(2) as the cut-off value, the product achieved 92% accuracy in identifying AD in the combined cohorts. Overall findings support that plasma Aβ42 and tau assayed by IMR technology can be used to assist in the clinical diagnosis of AD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 66 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 18% |
| Student > Master | 10 | 15% |
| Other | 7 | 11% |
| Student > Bachelor | 6 | 9% |
| Student > Ph. D. Student | 6 | 9% |
| Other | 10 | 15% |
| Unknown | 15 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 17% |
| Neuroscience | 11 | 17% |
| Agricultural and Biological Sciences | 7 | 11% |
| Chemistry | 5 | 8% |
| Psychology | 4 | 6% |
| Other | 10 | 15% |
| Unknown | 18 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 February 2021.
All research outputs
#2,442,241
of 22,996,001 outputs
Outputs from Frontiers in Aging Neuroscience
#811
of 4,836 outputs
Outputs of similar age
#48,552
of 316,521 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#23
of 110 outputs
Altmetric has tracked 22,996,001 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,836 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,521 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.