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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, July 2017
|
| DOI | 10.3389/fnagi.2017.00234 |
| Pubmed ID | |
| Authors |
Harald Lund, Melanie Pieber, Robert A. Harris |
| Abstract |
While bone marrow-derived Ly6C(hi) monocytes can infiltrate the central nervous system (CNS) they are developmentally and functionally distinct from resident microglia. Our understanding of the relative importance of these two populations in the distinct processes of pathogenesis and resolution of inflammation during neurodegenerative disorders was limited by a lack of tools to specifically manipulate each cell type. During recent years, the development of experimental cell-specific depletion models has enabled this issue to be addressed. Herein we compare and contrast the different depletion approaches that have been used, focusing on the respective functionalities of microglia and monocyte-derived macrophages in a range of neurodegenerative disease states, and discuss their prospects for immunotherapy. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 19% |
| Researcher | 11 | 14% |
| Student > Master | 9 | 11% |
| Student > Bachelor | 9 | 11% |
| Student > Doctoral Student | 4 | 5% |
| Other | 15 | 19% |
| Unknown | 17 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 20 | 25% |
| Agricultural and Biological Sciences | 14 | 18% |
| Medicine and Dentistry | 9 | 11% |
| Biochemistry, Genetics and Molecular Biology | 8 | 10% |
| Immunology and Microbiology | 3 | 4% |
| Other | 6 | 8% |
| Unknown | 20 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2017.
All research outputs
#14,950,579
of 22,996,001 outputs
Outputs from Frontiers in Aging Neuroscience
#3,378
of 4,836 outputs
Outputs of similar age
#188,125
of 316,684 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#77
of 105 outputs
Altmetric has tracked 22,996,001 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,836 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,684 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 105 others from the same source and published within six weeks on either side of this one. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.