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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Insulin-Like Growth Factor-1 and Neuroinflammation
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, November 2017
|
| DOI | 10.3389/fnagi.2017.00365 |
| Pubmed ID | |
| Authors |
Jose L. Labandeira-Garcia, Maria A. Costa-Besada, Carmen M. Labandeira, Begoña Villar-Cheda, Ana I. Rodríguez-Perez |
| Abstract |
Insulin-like growth factor-1 (IGF-1) effects on aging and neurodegeneration is still controversial. However, it is widely admitted that IGF-1 is involved in the neuroinflammatory response. In peripheral tissues, several studies showed that IGF-1 inhibited the expression of inflammatory markers, although other studies concluded that IGF-1 has proinflammatory functions. Furthermore, proinflammatory cytokines such as TNF-α impaired IGF-1 signaling. In the brain, there are controversial results on effects of IGF-1 in neuroinflammation. In addition to direct protective effects on neurons, several studies revealed anti-inflammatory effects of IGF-1 acting on astrocytes and microglia, and that IGF-1 may also inhibit blood brain barrier permeability. Altogether suggests that the aging-related decrease in IGF-1 levels may contribute to the aging-related pro-inflammatory state. IGF-1 inhibits the astrocytic response to inflammatory stimuli, and modulates microglial phenotype (IGF-1 promotes the microglial M2 and inhibits of M1 phenotype). Furthermore, IGF-1 is mitogenic for microglia. IGF-1 and estrogen interact to modulate the neuroinflammatory response and microglial and astrocytic phenotypes. Brain renin-angiotensin and IGF-1 systems also interact to modulate neuroinflammation. Induction of microglial IGF-1 by angiotensin, and possibly by other pro-inflammatory inducers, plays a major role in the repression of the M1 microglial neurotoxic phenotype and the enhancement of the transition to an M2 microglial repair/regenerative phenotype. This mechanism is impaired in aged brains. Aging-related decrease in IGF-1 may contribute to the loss of capacity of microglia to undergo M2 activation. Fine tuning of IGF-1 levels may be critical for regulating the neuroinflammatory response, and IGF-1 may be involved in inflammation in a context-dependent mode. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 20% |
| Switzerland | 1 | 20% |
| Unknown | 3 | 60% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 199 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 199 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 15% |
| Researcher | 22 | 11% |
| Student > Master | 22 | 11% |
| Student > Bachelor | 19 | 10% |
| Student > Doctoral Student | 13 | 7% |
| Other | 40 | 20% |
| Unknown | 53 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 39 | 20% |
| Biochemistry, Genetics and Molecular Biology | 25 | 13% |
| Medicine and Dentistry | 22 | 11% |
| Agricultural and Biological Sciences | 15 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 11 | 6% |
| Other | 25 | 13% |
| Unknown | 62 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 November 2017.
All research outputs
#13,337,759
of 23,008,860 outputs
Outputs from Frontiers in Aging Neuroscience
#2,884
of 4,843 outputs
Outputs of similar age
#161,194
of 329,032 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#57
of 111 outputs
Altmetric has tracked 23,008,860 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,843 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.1. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,032 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 111 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.