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Mendeley readers
Attention Score in Context
| Title |
Hippocampal Transcriptomic Profiles: Subfield Vulnerability to Age and Cognitive Impairment
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, December 2017
|
| DOI | 10.3389/fnagi.2017.00383 |
| Pubmed ID | |
| Authors |
Lara Ianov, Matt De Both, Monica K. Chawla, Asha Rani, Andrew J. Kennedy, Ignazio Piras, Jeremy J. Day, Ashley Siniard, Ashok Kumar, J. David Sweatt, Carol A. Barnes, Matthew J. Huentelman, Thomas C. Foster |
| Abstract |
The current study employed next-generation RNA sequencing to examine gene expression differences related to brain aging, cognitive decline, and hippocampal subfields. Young and aged rats were trained on a spatial episodic memory task. Hippocampal regions CA1, CA3, and the dentate gyrus were isolated. Poly-A mRNA was examined using two different sequencing platforms, Illumina, and Ion Proton. The Illumina platform was used to generate seed lists of genes that were statistically differentially expressed across regions, ages, or in association with cognitive function. The gene lists were then retested using the data from the Ion Proton platform. The results indicate hippocampal subfield differences in gene expression and point to regional differences in vulnerability to aging. Aging was associated with increased expression of immune response-related genes, particularly in the dentate gyrus. For the memory task, impaired performance of aged animals was linked to the regulation of Ca2+ and synaptic function in region CA1. Finally, we provide a transcriptomic characterization of the three subfields regardless of age or cognitive status, highlighting and confirming a correspondence between cytoarchitectural boundaries and molecular profiling. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 75% |
| Switzerland | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 45 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 20% |
| Student > Doctoral Student | 9 | 20% |
| Student > Ph. D. Student | 6 | 13% |
| Student > Bachelor | 5 | 11% |
| Professor | 2 | 4% |
| Other | 5 | 11% |
| Unknown | 9 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 20% |
| Biochemistry, Genetics and Molecular Biology | 6 | 13% |
| Agricultural and Biological Sciences | 5 | 11% |
| Psychology | 5 | 11% |
| Medicine and Dentistry | 2 | 4% |
| Other | 3 | 7% |
| Unknown | 15 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2017.
All research outputs
#13,583,859
of 23,867,274 outputs
Outputs from Frontiers in Aging Neuroscience
#2,991
of 5,074 outputs
Outputs of similar age
#209,133
of 445,974 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#57
of 106 outputs
Altmetric has tracked 23,867,274 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,074 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.6. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 445,974 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.