Title |
Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases
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Published in |
Frontiers in Aging Neuroscience, December 2017
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DOI | 10.3389/fnagi.2017.00406 |
Pubmed ID | |
Authors |
Pauline Gaignard, Philippe Liere, Patrice Thérond, Michael Schumacher, Abdelhamid Slama, Rachida Guennoun |
Abstract |
The mitochondria have a fundamental role in both cellular energy supply and oxidative stress regulation and are target of the effects of sex steroids, particularly the neuroprotective ones. Aging is associated with a decline in the levels of different steroid hormones, and this decrease may underline some neural dysfunctions. Besides, modifications in mitochondrial functions associated with aging processes are also well documented. In this review, we will discuss studies that describe the modifications of brain mitochondrial function and of steroid levels associated with physiological aging and with neurodegenerative diseases. A special emphasis will be placed on describing and discussing our recent findings concerning the concomitant study of mitochondrial function (oxidative phosphorylation, oxidative stress) and brain steroid levels in both young (3-month-old) and aged (20-month-old) male and female mice. |
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Geographical breakdown
Country | Count | As % |
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United States | 4 | 36% |
Netherlands | 1 | 9% |
Poland | 1 | 9% |
Switzerland | 1 | 9% |
Unknown | 4 | 36% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 6 | 55% |
Scientists | 5 | 45% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 103 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 18 | 17% |
Student > Ph. D. Student | 15 | 15% |
Student > Master | 14 | 14% |
Student > Bachelor | 13 | 13% |
Student > Doctoral Student | 12 | 12% |
Other | 16 | 16% |
Unknown | 15 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 21 | 20% |
Biochemistry, Genetics and Molecular Biology | 19 | 18% |
Agricultural and Biological Sciences | 10 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 10% |
Medicine and Dentistry | 8 | 8% |
Other | 12 | 12% |
Unknown | 23 | 22% |