Title |
Use of Peptides for the Management of Alzheimer’s Disease: Diagnosis and Inhibition
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Published in |
Frontiers in Aging Neuroscience, February 2018
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DOI | 10.3389/fnagi.2018.00021 |
Pubmed ID | |
Authors |
Mohammad H. Baig, Khurshid Ahmad, Gulam Rabbani, Inho Choi |
Abstract |
Alzheimer's disease (AD) is a form of dementia and the most common progressive neurodegenerative disease (ND). The targeting of amyloid-beta (Aβ) aggregation is one of the most widely used strategies to manage AD, and efforts are being made globally to develop peptide-based compounds for the early diagnosis and treatment of AD. Here, we briefly discuss the use of peptide-based compounds for the early diagnosis and treatment of AD and the use of peptide-based inhibitors targeting various Aβ aggregation checkpoints. In addition, we briefly discuss recent applications of peptide-based inhibitors against various AD targets including amyloid beta, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), tyrosine phosphatase (TP) and potassium channel KV1.3. |
X Demographics
Geographical breakdown
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Switzerland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 97 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 18 | 19% |
Student > Bachelor | 15 | 15% |
Student > Ph. D. Student | 9 | 9% |
Student > Master | 9 | 9% |
Student > Postgraduate | 4 | 4% |
Other | 8 | 8% |
Unknown | 34 | 35% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 24 | 25% |
Chemistry | 12 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
Neuroscience | 2 | 2% |
Agricultural and Biological Sciences | 2 | 2% |
Other | 10 | 10% |
Unknown | 40 | 41% |