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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Review of the Pedunculopontine Nucleus in Parkinson's Disease
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, April 2018
|
| DOI | 10.3389/fnagi.2018.00099 |
| Pubmed ID | |
| Authors |
Isobel T. French, Kalai A. Muthusamy |
| Abstract |
The pedunculopontine nucleus (PPN) is situated in the upper pons in the dorsolateral portion of the ponto-mesencephalic tegmentum. Its main mass is positioned at the trochlear nucleus level, and is part of the mesenphalic locomotor region (MLR) in the upper brainstem. The human PPN is divided into two subnuclei, the pars compacta (PPNc) and pars dissipatus (PPNd), and constitutes both cholinergic and non-cholinergic neurons with afferent and efferent projections to the cerebral cortex, thalamus, basal ganglia (BG), cerebellum, and spinal cord. The BG controls locomotion and posture via GABAergic output of the substantia nigra pars reticulate (SNr). In PD patients, GABAergic BG output levels are abnormally increased, and gait disturbances are produced via abnormal increases in SNr-induced inhibition of the MLR. Since the PPN is vastly connected with the BG and the brainstem, dysfunction within these systems lead to advanced symptomatic progression in Parkinson's disease (PD), including sleep and cognitive issues. To date, the best treatment is to perform deep brain stimulation (DBS) on PD patients as outcomes have shown positive effects in ameliorating the debilitating symptoms of this disease by treating pathological circuitries within the parkinsonian brain. It is therefore important to address the challenges and develop this procedure to improve the quality of life of PD patients. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 2 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 50% |
| Scientists | 2 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 216 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 216 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 13% |
| Student > Master | 29 | 13% |
| Student > Bachelor | 25 | 12% |
| Student > Ph. D. Student | 20 | 9% |
| Student > Postgraduate | 13 | 6% |
| Other | 37 | 17% |
| Unknown | 63 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 59 | 27% |
| Medicine and Dentistry | 34 | 16% |
| Psychology | 12 | 6% |
| Agricultural and Biological Sciences | 8 | 4% |
| Biochemistry, Genetics and Molecular Biology | 7 | 3% |
| Other | 21 | 10% |
| Unknown | 75 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 January 2024.
All research outputs
#1,186,023
of 25,808,886 outputs
Outputs from Frontiers in Aging Neuroscience
#275
of 5,575 outputs
Outputs of similar age
#25,394
of 341,027 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#11
of 113 outputs
Altmetric has tracked 25,808,886 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,575 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.5. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,027 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.