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X Demographics
Mendeley readers
Attention Score in Context
| Title |
APOE and Alzheimer’s Disease: Neuroimaging of Metabolic and Cerebrovascular Dysfunction
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, June 2018
|
| DOI | 10.3389/fnagi.2018.00180 |
| Pubmed ID | |
| Authors |
Jason A. Brandon, Brandon C. Farmer, Holden C. Williams, Lance A. Johnson |
| Abstract |
Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for late onset Alzheimer's Disease (AD), and is associated with impairments in cerebral metabolism and cerebrovascular function. A substantial body of literature now points to E4 as a driver of multiple impairments seen in AD, including blunted brain insulin signaling, mismanagement of brain cholesterol and fatty acids, reductions in blood brain barrier (BBB) integrity, and decreased cerebral glucose uptake. Various neuroimaging techniques, in particular positron emission topography (PET) and magnetic resonance imaging (MRI), have been instrumental in characterizing these metabolic and vascular deficits associated with this important AD risk factor. In the current mini-review article, we summarize the known effects of APOE on cerebral metabolism and cerebrovascular function, with a special emphasis on recent findings via neuroimaging approaches. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 25% |
| Spain | 1 | 6% |
| Canada | 1 | 6% |
| South Africa | 1 | 6% |
| Switzerland | 1 | 6% |
| United Kingdom | 1 | 6% |
| Unknown | 7 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 12 | 75% |
| Scientists | 4 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 91 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 19 | 21% |
| Student > Ph. D. Student | 17 | 19% |
| Student > Doctoral Student | 7 | 8% |
| Student > Master | 7 | 8% |
| Student > Bachelor | 6 | 7% |
| Other | 11 | 12% |
| Unknown | 24 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 26 | 29% |
| Biochemistry, Genetics and Molecular Biology | 11 | 12% |
| Agricultural and Biological Sciences | 6 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Nursing and Health Professions | 3 | 3% |
| Other | 12 | 13% |
| Unknown | 30 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 24. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2020.
All research outputs
#1,431,379
of 23,630,563 outputs
Outputs from Frontiers in Aging Neuroscience
#352
of 4,989 outputs
Outputs of similar age
#32,196
of 329,459 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#14
of 101 outputs
Altmetric has tracked 23,630,563 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,989 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.6. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,459 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.