You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Designing in vitro Blood-Brain Barrier Models Reproducing Alterations in Brain Aging
|
|---|---|
| Published in |
Frontiers in Aging Neuroscience, August 2018
|
| DOI | 10.3389/fnagi.2018.00234 |
| Pubmed ID | |
| Authors |
Elena D. Osipova, Yulia K. Komleva, Andrey V. Morgun, Olga L. Lopatina, Yulia A. Panina, Raissa Ya. Olovyannikova, Elizaveta F. Vais, Vladimir V. Salmin, Alla B. Salmina |
| Abstract |
Blood-brain barrier (BBB) modeling in vitro is a huge area of research covering study of intercellular communications and development of BBB, establishment of specific properties that provide controlled permeability of the barrier. Current approaches in designing new BBB models include development of new (bio) scaffolds supporting barriergenesis/angiogenesis and BBB integrity; use of methods enabling modulation of BBB permeability; application of modern analytical techniques for screening the transfer of metabolites, bio-macromolecules, selected drug candidates and drug delivery systems; establishment of 3D models; application of microfluidic technologies; reconstruction of microphysiological systems with the barrier constituents. Acceptance of idea that BBB in vitro models should resemble real functional activity of the barrier in different periods of ontogenesis and in different (patho) physiological conditions leads to proposal that establishment of BBB in vitro model with alterations specific for aging brain is one of current challenges in neurosciences and bioengineering. Vascular dysfunction in the aging brain often associates with leaky BBB, alterations in perivascular microenvironment, neuroinflammation, perturbed neuronal and astroglial activity within the neurovascular unit, impairments in neurogenic niches where microvascular scaffold plays a key regulatory role. The review article is focused on aging-related alterations in BBB and current approaches to development of "aging" BBB models in vitro. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 13% |
| France | 1 | 13% |
| Thailand | 1 | 13% |
| United Kingdom | 1 | 13% |
| Switzerland | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 75% |
| Scientists | 2 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 12 | 22% |
| Student > Master | 10 | 18% |
| Student > Doctoral Student | 8 | 15% |
| Researcher | 7 | 13% |
| Student > Ph. D. Student | 5 | 9% |
| Other | 3 | 5% |
| Unknown | 10 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 20% |
| Biochemistry, Genetics and Molecular Biology | 9 | 16% |
| Agricultural and Biological Sciences | 6 | 11% |
| Engineering | 4 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
| Other | 10 | 18% |
| Unknown | 11 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2018.
All research outputs
#8,508,506
of 25,375,376 outputs
Outputs from Frontiers in Aging Neuroscience
#3,155
of 5,481 outputs
Outputs of similar age
#133,723
of 337,388 outputs
Outputs of similar age from Frontiers in Aging Neuroscience
#55
of 90 outputs
Altmetric has tracked 25,375,376 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,481 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.4. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 337,388 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.