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Attention Score in Context
| Title |
LIM homeobox protein 5 (Lhx5) is essential for mamillary body development
|
|---|---|
| Published in |
Frontiers in Neuroanatomy, October 2015
|
| DOI | 10.3389/fnana.2015.00136 |
| Pubmed ID | |
| Authors |
Amaya Miquelajáuregui, Teresa Sandoval-Schaefer, Miriam Martínez-Armenta, Leonor Pérez-Martínez, Alfonso Cárabez, Yangu Zhao, Michael Heide, Gonzalo Alvarez-Bolado, Alfredo Varela-Echavarría |
| Abstract |
The mamillary body (MM) is a group of hypothalamic nuclei related to memory and spatial navigation that interconnects hippocampal, thalamic, and tegmental regions. Here we demonstrate that Lhx5, a LIM-HD domain transcription factor expressed early in the developing posterior hypothalamus, is required for the generation of the MM and its derived tracts. The MM markers Foxb1, Sim2, and Lhx1 are absent in Lhx5 knock-out mice from early embryonic stages, suggesting abnormal specification of this region. This was supported by the absence of Nkx2.1 and expansion of Shh in the prospective mamillary area. Interestingly, we also found an ectopic domain expressing Lhx2 and Lhx9 along the anterio-posterior hypothalamic axis. Our results suggest that Lhx5 controls early aspects of hypothalamic development by regulating gene expression and cellular specification in the prospective MM. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 4% |
| Unknown | 22 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 39% |
| Student > Ph. D. Student | 4 | 17% |
| Student > Bachelor | 2 | 9% |
| Professor > Associate Professor | 2 | 9% |
| Student > Doctoral Student | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 3 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 6 | 26% |
| Agricultural and Biological Sciences | 6 | 26% |
| Biochemistry, Genetics and Molecular Biology | 5 | 22% |
| Unknown | 6 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 October 2015.
All research outputs
#20,295,099
of 22,831,537 outputs
Outputs from Frontiers in Neuroanatomy
#1,009
of 1,160 outputs
Outputs of similar age
#238,654
of 284,522 outputs
Outputs of similar age from Frontiers in Neuroanatomy
#31
of 34 outputs
Altmetric has tracked 22,831,537 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,160 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 284,522 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.