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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Axonal Segregation and Role of the Vesicular Glutamate Transporter VGLUT3 in Serotonin Neurons
|
|---|---|
| Published in |
Frontiers in Neuroanatomy, April 2016
|
| DOI | 10.3389/fnana.2016.00039 |
| Pubmed ID | |
| Authors |
Aurore N. Voisin, Ouissame Mnie-Filali, Nicolas Giguère, Guillaume M. Fortin, Erika Vigneault, Salah El Mestikawy, Laurent Descarries, Louis-Éric Trudeau |
| Abstract |
A subset of monoamine neurons releases glutamate as a cotransmitter due to presence of the vesicular glutamate transporters VGLUT2 or VGLUT3. In addition to mediating vesicular loading of glutamate, it has been proposed that VGLUT3 enhances serotonin (5-HT) vesicular loading by the vesicular monoamine transporter (VMAT2) in 5-HT neurons. In dopamine (DA) neurons, glutamate appears to be released from specialized subsets of terminals and it may play a developmental role, promoting neuronal growth and survival. The hypothesis of a similar developmental role and axonal localization of glutamate co-release in 5-HT neurons has not been directly examined. Using postnatal mouse raphe neurons in culture, we first observed that in contrast to 5-HT itself, other phenotypic markers of 5-HT axon terminals such as the 5-HT reuptake transporter (SERT) show a more restricted localization in the axonal arborization. Interestingly, only a subset of SERT- and 5-HT-positive axonal varicosities expressed VGLUT3, with SERT and VGLUT3 being mostly segregated. Using VGLUT3 knockout mice, we found that deletion of this transporter leads to reduced survival of 5-HT neurons in vitro and also decreased the density of 5-HT-immunoreactivity in terminals in the dorsal striatum and dorsal part of the hippocampus in the intact brain. Our results demonstrate that raphe 5-HT neurons express SERT and VGLUT3 mainly in segregated axon terminals and that VGLUT3 regulates the vulnerability of these neurons and the neurochemical identity of their axonal domain, offering new perspectives on the functional connectivity of a cell population involved in anxiety disorders and depression. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 33% |
| Chile | 1 | 33% |
| Switzerland | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 58 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 25% |
| Student > Bachelor | 6 | 10% |
| Researcher | 6 | 10% |
| Student > Postgraduate | 3 | 5% |
| Student > Master | 3 | 5% |
| Other | 6 | 10% |
| Unknown | 20 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 19 | 32% |
| Agricultural and Biological Sciences | 15 | 25% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Medicine and Dentistry | 1 | 2% |
| Biochemistry, Genetics and Molecular Biology | 1 | 2% |
| Other | 2 | 3% |
| Unknown | 19 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 September 2019.
All research outputs
#14,844,479
of 22,860,626 outputs
Outputs from Frontiers in Neuroanatomy
#710
of 1,161 outputs
Outputs of similar age
#170,864
of 300,876 outputs
Outputs of similar age from Frontiers in Neuroanatomy
#24
of 43 outputs
Altmetric has tracked 22,860,626 research outputs across all sources so far. This one is in the 33rd percentile – i.e., 33% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,161 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.9. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 300,876 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 34th percentile – i.e., 34% of its contemporaries scored the same or lower than it.