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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Loud Noise Exposure Produces DNA, Neurotransmitter and Morphological Damage within Specific Brain Areas
|
|---|---|
| Published in |
Frontiers in Neuroanatomy, June 2017
|
| DOI | 10.3389/fnana.2017.00049 |
| Pubmed ID | |
| Authors |
Giada Frenzilli, Larisa Ryskalin, Michela Ferrucci, Emanuela Cantafora, Silvia Chelazzi, Filippo S. Giorgi, Paola Lenzi, Vittoria Scarcelli, Alessandro Frati, Francesca Biagioni, Stefano Gambardella, Alessandra Falleni, Francesco Fornai |
| Abstract |
Exposure to loud noise is a major environmental threat to public health. Loud noise exposure, apart from affecting the inner ear, is deleterious for cardiovascular, endocrine and nervous systems and it is associated with neuropsychiatric disorders. In this study we investigated DNA, neurotransmitters and immune-histochemical alterations induced by exposure to loud noise in three major brain areas (cerebellum, hippocampus, striatum) of Wistar rats. Rats were exposed to loud noise (100 dBA) for 12 h. The effects of noise on DNA integrity in all three brain areas were evaluated by using Comet assay. In parallel studies, brain monoamine levels and morphology of nigrostriatal pathways, hippocampus and cerebellum were analyzed at different time intervals (24 h and 7 days) after noise exposure. Loud noise produced a sudden increase in DNA damage in all the brain areas under investigation. Monoamine levels detected at 7 days following exposure were differently affected depending on the specific brain area. Namely, striatal but not hippocampal dopamine (DA) significantly decreased, whereas hippocampal and cerebellar noradrenaline (NA) was significantly reduced. This is in line with pathological findings within striatum and hippocampus consisting of a decrease in striatal tyrosine hydroxylase (TH) combined with increased Bax and glial fibrillary acidic protein (GFAP). Loud noise exposure lasting 12 h causes immediate DNA, and long-lasting neurotransmitter and immune-histochemical alterations within specific brain areas of the rat. These alterations may suggest an anatomical and functional link to explain the neurobiology of diseases which prevail in human subjects exposed to environmental noise. |
X Demographics
The data shown below were collected from the profiles of 17 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 41% |
| Turkey | 1 | 6% |
| Switzerland | 1 | 6% |
| Unknown | 8 | 47% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 48 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 21% |
| Other | 5 | 10% |
| Student > Ph. D. Student | 5 | 10% |
| Student > Master | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Other | 8 | 17% |
| Unknown | 13 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 19% |
| Biochemistry, Genetics and Molecular Biology | 4 | 8% |
| Engineering | 2 | 4% |
| Chemistry | 2 | 4% |
| Medicine and Dentistry | 2 | 4% |
| Other | 9 | 19% |
| Unknown | 20 | 42% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2024.
All research outputs
#1,933,392
of 25,998,826 outputs
Outputs from Frontiers in Neuroanatomy
#90
of 1,272 outputs
Outputs of similar age
#36,608
of 332,226 outputs
Outputs of similar age from Frontiers in Neuroanatomy
#2
of 25 outputs
Altmetric has tracked 25,998,826 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,272 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,226 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.