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New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?

Overview of attention for article published in Frontiers in Behavioral Neuroscience, January 2010
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (58th percentile)

Mentioned by

facebook
1 Facebook page
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
27 Dimensions

Readers on

mendeley
83 Mendeley
citeulike
2 CiteULike
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Title
New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?
Published in
Frontiers in Behavioral Neuroscience, January 2010
DOI 10.3389/fnbeh.2010.00023
Pubmed ID
Authors

Vanessa Nieratschker, Markus M. Nöthen, Marcella Rietschel

Abstract

Schizophrenia is a highly heritable disorder, but the identification of specific genes has proven to be a difficult endeavor. Genes involved in the dopaminergic system are considered to be major candidates since the "dopamine hypothesis" of impairment in dopaminergic neurotransmission is one of the most widely accepted hypotheses of the etiology of schizophrenia. The overall findings from candidate studies do provide some support for the "dopamine hypothesis." However, results from the first systematic genome-wide association (GWA) studies have implicated variants within ZNF804A, NRGN, TCF4, and variants in the MHC region on chromosome 6p22.1. Although these genes may not immediately impact on dopaminergic neurotransmission, it remains possible that downstream impairments in dopaminergic function are caused. Furthermore, only a very small fraction of all truly associated genetic variants have been detected and many more associated variants will be identified in the future by GWA studies and alternative approaches. The results of these studies may allow a more comprehensive re-evaluation of the dopamine hypothesis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
Hungary 1 1%
China 1 1%
Unknown 79 95%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 20%
Student > Bachelor 12 14%
Professor > Associate Professor 10 12%
Student > Master 8 10%
Professor 7 8%
Other 20 24%
Unknown 9 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 24%
Medicine and Dentistry 19 23%
Psychology 12 14%
Neuroscience 10 12%
Biochemistry, Genetics and Molecular Biology 4 5%
Other 8 10%
Unknown 10 12%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2021.
All research outputs
#7,179,139
of 22,694,633 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,201
of 3,145 outputs
Outputs of similar age
#47,071
of 163,579 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#11
of 29 outputs
Altmetric has tracked 22,694,633 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 3,145 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,579 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.