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Endocannabinoid System and Psychiatry: In Search of a Neurobiological Basis for Detrimental and Potential Therapeutic Effects

Overview of attention for article published in Frontiers in Behavioral Neuroscience, January 2011
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  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (73rd percentile)

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Title
Endocannabinoid System and Psychiatry: In Search of a Neurobiological Basis for Detrimental and Potential Therapeutic Effects
Published in
Frontiers in Behavioral Neuroscience, January 2011
DOI 10.3389/fnbeh.2011.00063
Pubmed ID
Authors

Eva M. Marco, María S. García-Gutiérrez, Francisco-Javier Bermúdez-Silva, Fabricio A. Moreira, Francisco Guimarães, Jorge Manzanares, María-Paz Viveros

Abstract

Public concern on mental health has noticeably increased given the high prevalence of neuropsychiatric disorders. Cognition and emotionality are the most affected functions in neuropsychiatric disorders, i.e., anxiety disorders, depression, and schizophrenia. In this review, most relevant literature on the role of the endocannabinoid (eCB) system in neuropsychiatric disorders will be presented. Evidence from clinical and animal studies is provided for the participation of CB1 and CB2 receptors (CB1R and CB2R) in the above mentioned neuropsychiatric disorders. CBRs are crucial in some of the emotional and cognitive impairments reported, although more research is required to understand the specific role of the eCB system in neuropsychiatric disorders. Cannabidiol (CBD), the main non-psychotropic component of the Cannabis sativa plant, has shown therapeutic potential in several neuropsychiatric disorders. Although further studies are needed, recent studies indicate that CBD therapeutic effects may partially depend on facilitation of eCB-mediated neurotransmission. Last but not least, this review includes recent findings on the role of the eCB system in eating disorders. A deregulation of the eCB system has been proposed to be in the bases of several neuropsychiatric disorders, including eating disorders. Cannabis consumption has been related to the appearance of psychotic symptoms and schizophrenia. In contrast, the pharmacological manipulation of this eCB system has been proposed as a potential strategy for the treatment of anxiety disorders, depression, and anorexia nervosa. In conclusion, the eCB system plays a critical role in psychiatry; however, detrimental consequences of manipulating this endogenous system cannot be underestimated over the potential and promising perspectives of its therapeutic manipulation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 264 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 <1%
United States 2 <1%
Spain 2 <1%
Canada 1 <1%
Switzerland 1 <1%
Israel 1 <1%
Romania 1 <1%
Unknown 254 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 48 18%
Student > Ph. D. Student 45 17%
Student > Master 29 11%
Researcher 26 10%
Student > Doctoral Student 16 6%
Other 55 21%
Unknown 45 17%
Readers by discipline Count As %
Medicine and Dentistry 54 20%
Psychology 35 13%
Agricultural and Biological Sciences 35 13%
Neuroscience 33 13%
Pharmacology, Toxicology and Pharmaceutical Science 13 5%
Other 41 16%
Unknown 53 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2020.
All research outputs
#6,632,722
of 24,506,807 outputs
Outputs from Frontiers in Behavioral Neuroscience
#994
of 3,365 outputs
Outputs of similar age
#47,332
of 189,072 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#13
of 46 outputs
Altmetric has tracked 24,506,807 research outputs across all sources so far. This one has received more attention than most of these and is in the 72nd percentile.
So far Altmetric has tracked 3,365 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 189,072 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 46 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.