Title |
The endocannabinoid system: an overview
|
---|---|
Published in |
Frontiers in Behavioral Neuroscience, January 2012
|
DOI | 10.3389/fnbeh.2012.00009 |
Pubmed ID | |
Authors |
Natalia Battista, Monia Di Tommaso, Monica Bari, Mauro Maccarrone |
Abstract |
Upon the identification of anandamide (AEA) in the porcine brain, numerous studies contributed to the current state of knowledge regarding all elements that form the "endocannabinoid system (ECS)."How this complex system of receptors, ligands, and enzymes is integrated in helping to regulate fundamental processes at level of central nervous and peripheral systems and how its regulation and dysregulation might counteract disturbances of such functions, is nowadays still under investigation. However, the most recent advances on the physiological distribution and functional role of ECS allowed the progress of various research tools aimed at the therapeutic exploitation of endocannabinoid (eCB) signaling, as well as the development of novel drugs with pharmacological advantages. Here, we shall briefly overview the metabolic and signal transduction pathways of the main eCBs representatives, AEA, and 2-arachidonoylglycerol (2-AG), and we will discuss the therapeutic potential of new ECS-oriented drugs. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 8 | 50% |
Switzerland | 1 | 6% |
Unknown | 7 | 44% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 15 | 94% |
Scientists | 1 | 6% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | <1% |
Italy | 2 | <1% |
Netherlands | 1 | <1% |
Ecuador | 1 | <1% |
Germany | 1 | <1% |
Unknown | 424 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 83 | 19% |
Student > Master | 66 | 15% |
Student > Ph. D. Student | 48 | 11% |
Researcher | 44 | 10% |
Student > Doctoral Student | 26 | 6% |
Other | 48 | 11% |
Unknown | 117 | 27% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 65 | 15% |
Agricultural and Biological Sciences | 56 | 13% |
Biochemistry, Genetics and Molecular Biology | 40 | 9% |
Neuroscience | 36 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 32 | 7% |
Other | 78 | 18% |
Unknown | 125 | 29% |