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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Restoration of hippocampal growth hormone reverses stress-induced hippocampal impairment
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, January 2013
|
| DOI | 10.3389/fnbeh.2013.00066 |
| Pubmed ID | |
| Authors |
Caitlin M. Vander Weele, Christopher Saenz, Junmei Yao, Susana S. Correia, Ki A. Goosens |
| Abstract |
Though growth hormone (GH) is synthesized by hippocampal neurons, where its expression is influenced by stress exposure, its function is poorly characterized. Here, we show that a regimen of chronic stress that impairs hippocampal function in rats also leads to a profound decrease in hippocampal GH levels. Restoration of hippocampal GH in the dorsal hippocampus via viral-mediated gene transfer completely reversed stress-related impairment of two hippocampus-dependent behavioral tasks, auditory trace fear conditioning, and contextual fear conditioning, without affecting hippocampal function in unstressed control rats. GH overexpression reversed stress-induced decrements in both fear acquisition and long-term fear memory. These results suggest that loss of hippocampal GH contributes to hippocampal dysfunction following prolonged stress and demonstrate that restoring hippocampal GH levels following stress can promote stress resilience. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 2% |
| Unknown | 45 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 24% |
| Student > Master | 6 | 13% |
| Student > Bachelor | 6 | 13% |
| Researcher | 5 | 11% |
| Student > Doctoral Student | 3 | 7% |
| Other | 7 | 15% |
| Unknown | 8 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 24% |
| Agricultural and Biological Sciences | 7 | 15% |
| Medicine and Dentistry | 6 | 13% |
| Psychology | 4 | 9% |
| Engineering | 4 | 9% |
| Other | 7 | 15% |
| Unknown | 7 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 June 2019.
All research outputs
#6,926,576
of 22,712,476 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,141
of 3,148 outputs
Outputs of similar age
#75,765
of 280,743 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#55
of 165 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 3,148 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,743 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 165 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.