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Modulation of social behavior by the agouti pigmentation gene

Overview of attention for article published in Frontiers in Behavioral Neuroscience, August 2014
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Title
Modulation of social behavior by the agouti pigmentation gene
Published in
Frontiers in Behavioral Neuroscience, August 2014
DOI 10.3389/fnbeh.2014.00259
Pubmed ID
Authors

Valeria Carola, Emerald Perlas, Francesca Zonfrillo, Helena A. Soini, Milos V. Novotny, Cornelius T. Gross

Abstract

Agouti is a secreted neuropeptide that acts as an endogenous antagonist of melanocortin receptors. Mice and rats lacking agouti (called non-agouti) have dark fur due to a disinhibition of melanocortin signaling and pigment deposition in the hair follicle. Non-agouti animals have also been reported to exhibit altered behavior, despite no evidence for the expression of agouti outside the skin. Here we confirm that non-agouti mice show altered social behavior and uncover expression of agouti in the preputial gland, a sebaceous organ in the urinary tract that secretes molecules involved in social behavior. Non-agouti mice had enlarged preputial glands and altered levels of putative preputial pheromones and surgical removal of the gland reversed the behavioral phenotype. These findings demonstrate the existence of an autologous, out-of-skin pathway for the modulation of social behavior.

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The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 4%
Unknown 25 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 8 31%
Student > Ph. D. Student 8 31%
Student > Doctoral Student 3 12%
Student > Bachelor 2 8%
Student > Postgraduate 2 8%
Other 3 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 46%
Neuroscience 3 12%
Biochemistry, Genetics and Molecular Biology 2 8%
Psychology 2 8%
Computer Science 1 4%
Other 2 8%
Unknown 4 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 January 2021.
All research outputs
#14,199,380
of 22,761,738 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,886
of 3,160 outputs
Outputs of similar age
#118,437
of 229,520 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#40
of 72 outputs
Altmetric has tracked 22,761,738 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,160 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 229,520 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.