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Mendeley readers
Attention Score in Context
| Title |
The Role of the Hippocampus in Avoidance Learning and Anxiety Vulnerability
|
|---|---|
| Published in |
Frontiers in Behavioral Neuroscience, August 2014
|
| DOI | 10.3389/fnbeh.2014.00273 |
| Pubmed ID | |
| Authors |
Tara P. Cominski, Xilu Jiao, Jennifer E. Catuzzi, Amanda L. Stewart, Kevin C. H. Pang |
| Abstract |
The hippocampus has been implicated in anxiety disorders and post-traumatic stress disorder (PTSD); human studies suggest that a dysfunctional hippocampus may be a vulnerability factor for the development of PTSD. In the current study, we examined the effect of hippocampal damage in avoidance learning, as avoidance is a core symptom of all anxiety disorders. First, the effect of hippocampal damage on avoidance learning was investigated in outbred Sprague Dawley (SD) rats. Second, the function of the hippocampus in Wistar-Kyoto (WKY) rats was compared to SD rats. The WKY rat is an animal model of behavioral inhibition, a risk factor for anxiety, and demonstrates abnormal avoidance learning, marked by facilitated avoidance acquisition and resistance to extinction. The results of the current study indicate that hippocampal damage in SD rats leads to impaired extinction of avoidance learning similar to WKY rats. Furthermore, WKY rats have reduced hippocampal volume and impaired hippocampal synaptic plasticity as compared to SD rats. These results suggest that hippocampal dysfunction enhances the development of persistent avoidance responding and, thus, may confer vulnerability to the development of anxiety disorders and PTSD. |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | <1% |
| Unknown | 113 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 26% |
| Student > Master | 15 | 13% |
| Student > Bachelor | 13 | 11% |
| Researcher | 7 | 6% |
| Student > Doctoral Student | 5 | 4% |
| Other | 20 | 18% |
| Unknown | 24 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 29 | 25% |
| Psychology | 21 | 18% |
| Agricultural and Biological Sciences | 20 | 18% |
| Medicine and Dentistry | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 9 | 8% |
| Unknown | 26 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 20. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 August 2022.
All research outputs
#1,622,966
of 23,025,074 outputs
Outputs from Frontiers in Behavioral Neuroscience
#259
of 3,201 outputs
Outputs of similar age
#17,499
of 231,248 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#6
of 75 outputs
Altmetric has tracked 23,025,074 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,201 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.3. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,248 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 75 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.