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Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment

Overview of attention for article published in Frontiers in Behavioral Neuroscience, October 2014
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1 Redditor

Citations

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67 Mendeley
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Title
Role of dopamine D2 receptors in optimizing choice strategy in a dynamic and uncertain environment
Published in
Frontiers in Behavioral Neuroscience, October 2014
DOI 10.3389/fnbeh.2014.00368
Pubmed ID
Authors

Shinae Kwak, Namjung Huh, Ji-Seon Seo, Jung-Eun Lee, Pyung-Lim Han, Min W. Jung

Abstract

In order to investigate roles of dopamine receptor subtypes in reward-based learning, we examined choice behavior of dopamine D1 and D2 receptor-knockout (D1R-KO and D2R-KO, respectively) mice in an instrumental learning task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Performance of D2R-KO mice was progressively impaired in the former as the frequency of reversal increased and profoundly impaired in the latter even with prolonged training, whereas D1R-KO mice showed relatively minor performance deficits. Choice behavior in the dynamic two-armed bandit task was well explained by a hybrid model including win-stay-lose-switch and reinforcement learning terms. A model-based analysis revealed increased win-stay, but impaired value updating and decreased value-dependent action selection in D2R-KO mice, which were detrimental to maximizing rewards in the dynamic two-armed bandit task. These results suggest an important role of dopamine D2 receptors in learning from past choice outcomes for rapid adjustment of choice behavior in a dynamic and uncertain environment.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 3%
Sweden 1 1%
China 1 1%
Japan 1 1%
United States 1 1%
Unknown 61 91%

Demographic breakdown

Readers by professional status Count As %
Researcher 16 24%
Student > Ph. D. Student 15 22%
Student > Bachelor 8 12%
Student > Master 6 9%
Other 3 4%
Other 7 10%
Unknown 12 18%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 22%
Neuroscience 15 22%
Psychology 7 10%
Medicine and Dentistry 4 6%
Social Sciences 4 6%
Other 5 7%
Unknown 17 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 October 2014.
All research outputs
#20,242,136
of 22,769,322 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,823
of 3,161 outputs
Outputs of similar age
#217,145
of 260,385 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#81
of 94 outputs
Altmetric has tracked 22,769,322 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,161 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 260,385 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 94 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.