Title |
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders
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Published in |
Frontiers in Behavioral Neuroscience, December 2014
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DOI | 10.3389/fnbeh.2014.00440 |
Pubmed ID | |
Authors |
Jeremy D. Coplan, Sasha L. Fulton, Wade Reiner, Andrea Jackowski, Venkatesh Panthangi, Tarique D. Perera, Jack M. Gorman, Yung-yu Huang, Cheuk Y. Tang, Patrick R. Hof, Arie Kaffman, Andrew J. Dwork, Sanjay J. Mathew, Joan Kaufman, J. John Mann |
Abstract |
Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of ELS, utilizing the variable foraging demand (VFD) macaque model, on adolescent monoamine metabolites. We sought to replicate an increase in cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) observed in two previous VFD cohorts. We hypothesized that elevated cisternal 5-HIAA was associated with reduced neurotrophic effects, conceivably due to excessive negative feedback at somatodendritic 5-HT1A autoreceptors. A putatively decreased serotonin neurotransmission would be reflected by reductions in hippocampal volume and white matter (WM) fractional anisotropy (FA). |
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