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Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related…

Overview of attention for article published in Frontiers in Behavioral Neuroscience, December 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

news
6 news outlets
blogs
5 blogs

Citations

dimensions_citation
15 Dimensions

Readers on

mendeley
56 Mendeley
citeulike
1 CiteULike
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Title
Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders
Published in
Frontiers in Behavioral Neuroscience, December 2014
DOI 10.3389/fnbeh.2014.00440
Pubmed ID
Authors

Jeremy D. Coplan, Sasha L. Fulton, Wade Reiner, Andrea Jackowski, Venkatesh Panthangi, Tarique D. Perera, Jack M. Gorman, Yung-yu Huang, Cheuk Y. Tang, Patrick R. Hof, Arie Kaffman, Andrew J. Dwork, Sanjay J. Mathew, Joan Kaufman, J. John Mann

Abstract

Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of ELS, utilizing the variable foraging demand (VFD) macaque model, on adolescent monoamine metabolites. We sought to replicate an increase in cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) observed in two previous VFD cohorts. We hypothesized that elevated cisternal 5-HIAA was associated with reduced neurotrophic effects, conceivably due to excessive negative feedback at somatodendritic 5-HT1A autoreceptors. A putatively decreased serotonin neurotransmission would be reflected by reductions in hippocampal volume and white matter (WM) fractional anisotropy (FA).

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 2%
Brazil 1 2%
Unknown 54 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 18%
Researcher 7 13%
Student > Ph. D. Student 7 13%
Student > Bachelor 5 9%
Student > Doctoral Student 5 9%
Other 8 14%
Unknown 14 25%
Readers by discipline Count As %
Psychology 11 20%
Medicine and Dentistry 9 16%
Neuroscience 6 11%
Agricultural and Biological Sciences 5 9%
Nursing and Health Professions 2 4%
Other 4 7%
Unknown 19 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 74. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2015.
All research outputs
#487,601
of 22,793,427 outputs
Outputs from Frontiers in Behavioral Neuroscience
#79
of 3,165 outputs
Outputs of similar age
#6,639
of 352,914 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#5
of 64 outputs
Altmetric has tracked 22,793,427 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,165 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,914 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 64 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.