↓ Skip to main content

Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors

Overview of attention for article published in Frontiers in Behavioral Neuroscience, January 2015
Altmetric Badge

Mentioned by

twitter
1 X user

Readers on

mendeley
78 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors
Published in
Frontiers in Behavioral Neuroscience, January 2015
DOI 10.3389/fnbeh.2014.00448
Pubmed ID
Authors

Gregory Beaudet, Valentine Bouet, Christelle Jozet-Alves, Pascale Schumann-Bard, François Dauphin, Eleni Paizanis, Michel Boulouard, Thomas Freret

Abstract

Elderly persons often face biological, psychological or social changes over time that may cause discomfort or morbidity. While some cognitive domains remain stable over time, others undergo a decline. Spatial navigation is a complex cognitive function essential for independence, safety and quality of life. While egocentric (body-centered) navigation is quite preserved during aging, allocentric (externally-centered) navigation-based on a cognitive map using distant landmarks-declines with age. Recent preclinical studies showed that serotonergic 5-HT7 receptors are localized in brain regions associated with allocentric spatial navigation processing. Behavioral assessments with pharmacological or genetic tools have confirmed the role of 5-HT7 receptors in allocentric navigation. Moreover, few data suggested a selective age-related decrease in the expression of 5-HT7 receptors in pivotal brain structures implicated in allocentric navigation such as the hippocampal CA3 region. We aim to provide a short overview of the potential role of 5-HT7 receptors in spatial navigation, and to argue for their interests as therapeutic targets against age-related cognitive decline.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 1%
France 1 1%
Unknown 76 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 15 19%
Student > Ph. D. Student 10 13%
Student > Master 9 12%
Student > Bachelor 7 9%
Other 6 8%
Other 12 15%
Unknown 19 24%
Readers by discipline Count As %
Neuroscience 22 28%
Psychology 9 12%
Agricultural and Biological Sciences 6 8%
Medicine and Dentistry 5 6%
Chemistry 3 4%
Other 9 12%
Unknown 24 31%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2015.
All research outputs
#18,390,814
of 22,780,165 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,598
of 3,163 outputs
Outputs of similar age
#256,766
of 353,655 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#61
of 72 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,163 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 10th percentile – i.e., 10% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,655 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.