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Disrupted thalamic resting-state functional networks in schizophrenia

Overview of attention for article published in Frontiers in Behavioral Neuroscience, February 2015
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Title
Disrupted thalamic resting-state functional networks in schizophrenia
Published in
Frontiers in Behavioral Neuroscience, February 2015
DOI 10.3389/fnbeh.2015.00045
Pubmed ID
Authors

Hsiao-Lan Sharon Wang, Chi-Lun Rau, Yu-Mei Li, Ya-Ping Chen, Rongjun Yu

Abstract

The thalamus plays a key role in filtering or gating information and has extensive interconnectivity with other brain regions. Recent studies provide evidence of thalamus abnormality in schizophrenia, but the resting functional networks of the thalamus in schizophrenia is still unclear. We characterize the thalamic resting-state networks (RSNs) in 72 patients with schizophrenia and 73 healthy controls, using a standard seed-based whole-brain correlation. In comparison with controls, patients exhibited enhance thalamic connectivity with bilateral precentral gyrus, dorsal medial frontal gyrus, middle occipital gyrus, and lingual gyrus. Reduced thalamic connectivity in schizophrenia was found in bilateral superior frontal gyrus, anterior cingualte cortex, inferior parietal lobe, and cerebellum. Our findings question the "disconnectivity model" of schizophrenia by showing the over-connected thalamic network during resting state in schizophrenia and highlight the thalamus as a key hub in the schizophrenic network abnormality.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 1%
Unknown 76 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 26%
Researcher 11 14%
Student > Master 11 14%
Student > Postgraduate 5 6%
Student > Doctoral Student 3 4%
Other 8 10%
Unknown 19 25%
Readers by discipline Count As %
Neuroscience 19 25%
Psychology 8 10%
Agricultural and Biological Sciences 7 9%
Medicine and Dentistry 4 5%
Engineering 3 4%
Other 10 13%
Unknown 26 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2015.
All research outputs
#20,264,045
of 22,794,367 outputs
Outputs from Frontiers in Behavioral Neuroscience
#2,826
of 3,165 outputs
Outputs of similar age
#215,346
of 255,477 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#63
of 69 outputs
Altmetric has tracked 22,794,367 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,165 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 11.4. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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