Title |
Prenatal predictors of infant self-regulation: the contributions of placental DNA methylation of NR3C1 and neuroendocrine activity
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Published in |
Frontiers in Behavioral Neuroscience, May 2015
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DOI | 10.3389/fnbeh.2015.00130 |
Pubmed ID | |
Authors |
Elisabeth Conradt, Mary Fei, Linda LaGasse, Edward Tronick, Dylan Guerin, Daniel Gorman, Carmen J. Marsit, Barry M. Lester |
Abstract |
We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still-face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode was coded and pre-stress cortisol and cortisol reactivity was assessed in response to the still-face paradigm. A factor analysis of NR3C1 CpG sites revealed two factors: one for CpG sites 1-4 and the other for sites 5-13. DNA methylation of the factor comprising NR3C1 CpG sites 5-13 was related to greater cortisol reactivity and infant self-regulation, but cortisol reactivity was not associated with infant self-regulation. The results reveal that prenatal epigenetic processes may explain part of the development of infant self-regulation. |
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United States | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
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Mendeley readers
Geographical breakdown
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United States | 1 | <1% |
Unknown | 101 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 20 | 20% |
Student > Ph. D. Student | 16 | 16% |
Student > Master | 13 | 13% |
Student > Bachelor | 12 | 12% |
Student > Doctoral Student | 10 | 10% |
Other | 13 | 13% |
Unknown | 18 | 18% |
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Neuroscience | 4 | 4% |
Other | 7 | 7% |
Unknown | 26 | 25% |