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Prenatal predictors of infant self-regulation: the contributions of placental DNA methylation of NR3C1 and neuroendocrine activity

Overview of attention for article published in Frontiers in Behavioral Neuroscience, May 2015
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  • Above-average Attention Score compared to outputs of the same age (54th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

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Citations

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102 Mendeley
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Title
Prenatal predictors of infant self-regulation: the contributions of placental DNA methylation of NR3C1 and neuroendocrine activity
Published in
Frontiers in Behavioral Neuroscience, May 2015
DOI 10.3389/fnbeh.2015.00130
Pubmed ID
Authors

Elisabeth Conradt, Mary Fei, Linda LaGasse, Edward Tronick, Dylan Guerin, Daniel Gorman, Carmen J. Marsit, Barry M. Lester

Abstract

We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still-face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode was coded and pre-stress cortisol and cortisol reactivity was assessed in response to the still-face paradigm. A factor analysis of NR3C1 CpG sites revealed two factors: one for CpG sites 1-4 and the other for sites 5-13. DNA methylation of the factor comprising NR3C1 CpG sites 5-13 was related to greater cortisol reactivity and infant self-regulation, but cortisol reactivity was not associated with infant self-regulation. The results reveal that prenatal epigenetic processes may explain part of the development of infant self-regulation.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 102 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Unknown 101 99%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 20%
Student > Ph. D. Student 16 16%
Student > Master 13 13%
Student > Bachelor 12 12%
Student > Doctoral Student 10 10%
Other 13 13%
Unknown 18 18%
Readers by discipline Count As %
Psychology 43 42%
Medicine and Dentistry 10 10%
Agricultural and Biological Sciences 8 8%
Biochemistry, Genetics and Molecular Biology 4 4%
Neuroscience 4 4%
Other 7 7%
Unknown 26 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 April 2023.
All research outputs
#14,554,594
of 25,641,627 outputs
Outputs from Frontiers in Behavioral Neuroscience
#1,477
of 3,484 outputs
Outputs of similar age
#127,213
of 280,018 outputs
Outputs of similar age from Frontiers in Behavioral Neuroscience
#41
of 89 outputs
Altmetric has tracked 25,641,627 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,484 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.5. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,018 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.